Visser SA - Search Results

1

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo.

Jonker DM, Visser SA, van der Graaf PH, Voskuyl RA, Danhof M. Jonker DM, et al. Among authors: visser sa. Pharmacol Ther. 2005 Apr;106(1):1-18. doi: 10.1016/j.pharmthera.2004.10.014. Epub 2004 Dec 23. Pharmacol Ther. 2005. PMID: 15781119 Review.

2

Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats.

Visser SA, Smulders CJ, Reijers BP, Van der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2002 Sep;302(3):1158-67. doi: 10.1124/jpet.302.3.1158. J Pharmacol Exp Ther. 2002. PMID: 12183676

3

Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo.

Visser SA, Gladdines WW, van der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):616-26. doi: 10.1124/jpet.102.039610. J Pharmacol Exp Ther. 2002. PMID: 12388643

4

Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations.

Visser SA, Wolters FL, Gubbens-Stibbe JM, Tukker E, Van Der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2003 Jan;304(1):88-101. doi: 10.1124/jpet.102.042341. J Pharmacol Exp Ther. 2003. PMID: 12490579

5

Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: focus on preclinical steps.

Danhof M, Visser SA. Danhof M, et al. Among authors: visser sa. Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:127-8. Methods Find Exp Clin Pharmacol. 2002. PMID: 12585231 No abstract available.

6

Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo.

Visser SA, Wolters FL, van der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1251-7. doi: 10.1124/jpet.102.044859. J Pharmacol Exp Ther. 2003. PMID: 12604703

7

Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats.

Visser SA, Huntjens DR, van der Graaf PH, Peletier LA, Danhof M. Visser SA, et al. J Pharmacol Exp Ther. 2003 Nov;307(2):765-75. doi: 10.1124/jpet.103.054510. Epub 2003 Sep 15. J Pharmacol Exp Ther. 2003. PMID: 12975494

8

Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo.

Van der Graaf PH, Van Schaick EA, Visser SA, De Greef HJ, Ijzerman AP, Danhof M. Van der Graaf PH, et al. Among authors: visser sa. J Pharmacol Exp Ther. 1999 Aug;290(2):702-9. J Pharmacol Exp Ther. 1999. PMID: 10411581

9

Model-based evaluation of drug-induced QTc prolongation for compounds in early development.

Dubois VF, Yu H, Danhof M, Della Pasqua O; Cardiovascular Safety Project Team and TI Pharma PKPD Platform. Dubois VF, et al. Br J Clin Pharmacol. 2015 Jan;79(1):148-61. doi: 10.1111/bcp.12482. Br J Clin Pharmacol. 2015. PMID: 25099645 Free PMC article. Clinical Trial.

10

Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.

Gotta V, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Among authors: visser sa. J Pharmacol Toxicol Methods. 2015 Mar-Apr;72:1-10. doi: 10.1016/j.vascn.2014.12.008. Epub 2014 Dec 31. J Pharmacol Toxicol Methods. 2015. PMID: 25556117

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