Pellecchia M - Search Results

1

Apoptosis-based therapies for hematologic malignancies.

Reed JC, Pellecchia M. Reed JC, et al. Among authors: pellecchia m. Blood. 2005 Jul 15;106(2):408-18. doi: 10.1182/blood-2004-07-2761. Epub 2005 Mar 29. Blood. 2005. PMID: 15797997 Free article. Review.

2

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy.

Placzek WJ, Wei J, Kitada S, Zhai D, Reed JC, Pellecchia M. Placzek WJ, et al. Among authors: pellecchia m. Cell Death Dis. 2010 May 6;1(5):e40. doi: 10.1038/cddis.2010.18. Cell Death Dis. 2010. PMID: 21364647 Free PMC article.

3

Robust lanthanide-based assays for the detection of anti-apoptotic Bcl-2-family protein antagonists.

Rega MF, Reed JC, Pellecchia M. Rega MF, et al. Among authors: pellecchia m. Bioorg Chem. 2007 Apr;35(2):113-20. doi: 10.1016/j.bioorg.2006.07.006. Epub 2006 Sep 22. Bioorg Chem. 2007. PMID: 16996562

4

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC. Kitada S, et al. Among authors: pellecchia m. Blood. 2008 Mar 15;111(6):3211-9. doi: 10.1182/blood-2007-09-113647. Epub 2008 Jan 17. Blood. 2008. PMID: 18202226 Free PMC article.

5

Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors.

Huang JW, Zhang Z, Wu B, Cellitti JF, Zhang X, Dahl R, Shiau CW, Welsh K, Emdadi A, Stebbins JL, Reed JC, Pellecchia M. Huang JW, et al. Among authors: pellecchia m. J Med Chem. 2008 Nov 27;51(22):7111-8. doi: 10.1021/jm8006992. J Med Chem. 2008. PMID: 18956862 Free PMC article.

6

Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.

Pan R, Ruvolo VR, Wei J, Konopleva M, Reed JC, Pellecchia M, Andreeff M, Ruvolo PP. Pan R, et al. Among authors: pellecchia m. Blood. 2015 Jul 16;126(3):363-72. doi: 10.1182/blood-2014-10-604975. Epub 2015 Jun 4. Blood. 2015. PMID: 26045609 Free PMC article.

7

Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L).

Becattini B, Kitada S, Leone M, Monosov E, Chandler S, Zhai D, Kipps TJ, Reed JC, Pellecchia M. Becattini B, et al. Among authors: pellecchia m. Chem Biol. 2004 Mar;11(3):389-95. doi: 10.1016/j.chembiol.2004.02.020. Chem Biol. 2004. PMID: 15123268

8

Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors.

Schimmer AD, Thomas MP, Hurren R, Gronda M, Pellecchia M, Pond GR, Konopleva M, Gurfinkel D, Mawji IA, Brown E, Reed JC. Schimmer AD, et al. Among authors: pellecchia m. Cancer Res. 2006 Feb 15;66(4):2367-75. doi: 10.1158/0008-5472.CAN-05-1061. Cancer Res. 2006. PMID: 16489043

9

Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid.

Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N, Pellecchia M. Becattini B, et al. Among authors: pellecchia m. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12602-6. doi: 10.1073/pnas.0603460103. Epub 2006 Aug 4. Proc Natl Acad Sci U S A. 2006. PMID: 16891420 Free PMC article.

10

Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists.

Wei J, Rega MF, Kitada S, Yuan H, Zhai D, Risbood P, Seltzman HH, Twine CE, Reed JC, Pellecchia M. Wei J, et al. Among authors: pellecchia m. Cancer Lett. 2009 Jan 8;273(1):107-13. doi: 10.1016/j.canlet.2008.07.031. Epub 2008 Sep 7. Cancer Lett. 2009. PMID: 18782651 Free PMC article.

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