Martinek V - Search Results

1

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH. Arlt VM, et al. Among authors: martinek v. Cancer Res. 2005 Apr 1;65(7):2644-52. doi: 10.1158/0008-5472.CAN-04-3544. Cancer Res. 2005. PMID: 15805261

2

Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.

Stiborová M, Frei E, Schmeiser HH, Arlt VM, Martínek V. Stiborová M, et al. Among authors: martinek v. Int J Mol Sci. 2014 Jun 10;15(6):10271-95. doi: 10.3390/ijms150610271. Int J Mol Sci. 2014. PMID: 24918288 Free PMC article. Review.

3

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

Stiborová M, Martínek V, Rýdlová H, Hodek P, Frei E. Stiborová M, et al. Among authors: martinek v. Cancer Res. 2002 Oct 15;62(20):5678-84. Cancer Res. 2002. PMID: 12384524

4

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment.

Reynisson J, Stiborová M, Martínek V, Gamboa da Costa G, Phillips DH, Arlt VM. Reynisson J, et al. Among authors: martinek v. Environ Mol Mutagen. 2008 Oct;49(8):659-67. doi: 10.1002/em.20411. Environ Mol Mutagen. 2008. PMID: 18618595 Free article.

5

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone.

Stiborová M, Martínek V, Svobodová M, Sístková J, Dvorák Z, Ulrichová J, Simánek V, Frei E, Schmeiser HH, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: martinek v. Chem Res Toxicol. 2010 Jul 19;23(7):1192-201. doi: 10.1021/tx100052d. Chem Res Toxicol. 2010. PMID: 20545351

6

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.

Stiborová M, Mareš J, Frei E, Arlt VM, Martínek V, Schmeiser HH. Stiborová M, et al. Among authors: martinek v. Environ Mol Mutagen. 2011 Jul;52(6):448-59. doi: 10.1002/em.20642. Epub 2011 Mar 2. Environ Mol Mutagen. 2011. PMID: 21370283

7

Comparison of activation of aristolochic acid I and II with NADPH:quinone oxidoreductase, sulphotransferases and N-acetyltranferases.

Martinek V, Kubickova B, Arlt VM, Frei E, Schmeiser HH, Hudecek J, Stiborova M. Martinek V, et al. Neuro Endocrinol Lett. 2011;32 Suppl 1:57-70. Neuro Endocrinol Lett. 2011. PMID: 22167209

8

Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Dračínská H, Martínek V, Svášková D, Hodek P, Milichovský J, Hejduková Ž, Brotánek J, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: martinek v. Chem Res Toxicol. 2013 Feb 18;26(2):290-9. doi: 10.1021/tx3004533. Epub 2013 Jan 15. Chem Res Toxicol. 2013. PMID: 23289503

9

A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.

Stiborová M, Bárta F, Levová K, Hodek P, Schmeiser HH, Arlt VM, Martínek V. Stiborová M, et al. Among authors: martinek v. Int J Mol Sci. 2015 Nov 18;16(11):27561-75. doi: 10.3390/ijms161126047. Int J Mol Sci. 2015. PMID: 26593908 Free PMC article.

10

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Milichovský J, Bárta F, Schmeiser HH, Arlt VM, Frei E, Stiborová M, Martínek V. Milichovský J, et al. Among authors: martinek v. Int J Mol Sci. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213. Int J Mol Sci. 2016. PMID: 26861298 Free PMC article.

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