De Cristofaro R - Search Results

1

Role of chloride ions in modulation of the interaction between von Willebrand factor and ADAMTS-13.

De Cristofaro R, Peyvandi F, Palla R, Lavoretano S, Lombardi R, Merati G, Romitelli F, Di Stasio E, Mannucci PM. De Cristofaro R, et al. J Biol Chem. 2005 Jun 17;280(24):23295-302. doi: 10.1074/jbc.M501143200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15809291 Free article.

2

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III.

De Cristofaro R, De Candia E, Rutella S, Weitz JI. De Cristofaro R, et al. Among authors: de candia e. J Biol Chem. 2000 Feb 11;275(6):3887-95. doi: 10.1074/jbc.275.6.3887. J Biol Chem. 2000. PMID: 10660541 Free article.

Thrombin binds to GpIb via its heparin-binding site (HBS) (De Candia, E., De Cristofaro, R., De Marco, L., Mazzucato, M., Picozzi, M., and Landolfi, R. (1997) Thromb. Haemostasis 77, 735-740; De Cristofaro, R., De …

Thrombin binds to GpIb via its heparin-binding site (HBS) (De Candia, E., De Cristofaro, R., De Marco, L. …

3

Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets.

De Candia E, Hall SW, Rutella S, Landolfi R, Andrews RK, De Cristofaro R. De Candia E, et al. Among authors: de cristofaro r. J Biol Chem. 2001 Feb 16;276(7):4692-8. doi: 10.1074/jbc.M008160200. Epub 2000 Nov 17. J Biol Chem. 2001. PMID: 11084032 Free article.

4

Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype.

Akhavan S, De Cristofaro R, Peyvandi F, Lavoretano S, Landolfi R, Mannucci PM. Akhavan S, et al. Among authors: de cristofaro r. Blood. 2002 Aug 15;100(4):1347-53. doi: 10.1182/blood-2002-01-0243. Blood. 2002. PMID: 12149217 Free article.

5

Two naturally occurring mutations on FVII gene (S363I-W364C) altering intrinsic catalytic activity.

Peyvandi F, De Cristofaro R, Akhavan S, Carew JA, Landolfi R, Bauer KA, Mannucci PM. Peyvandi F, et al. Among authors: de cristofaro r. Thromb Haemost. 2002 Nov;88(5):750-5. Thromb Haemost. 2002. PMID: 12428089

6

Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

De Cristofaro R, De Filippis V. De Cristofaro R, et al. Among authors: de filippis v. Biochem J. 2003 Jul 15;373(Pt 2):593-601. doi: 10.1042/BJ20030167. Biochem J. 2003. PMID: 12689334 Free PMC article.

7

A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.

De Cristofaro R, Akhavan S, Altomare C, Carotti A, Peyvandi F, Mannucci PM. De Cristofaro R, et al. J Biol Chem. 2004 Mar 26;279(13):13035-43. doi: 10.1074/jbc.M312430200. Epub 2004 Jan 13. J Biol Chem. 2004. PMID: 14722067 Free article.

8

The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency.

Peyvandi F, De Cristofaro R, Garagiola I, Palla R, Akhavan S, Landolfi R, Mannucci PM. Peyvandi F, et al. Among authors: de cristofaro r. Br J Haematol. 2004 Dec;127(5):576-84. doi: 10.1111/j.1365-2141.2004.05241.x. Br J Haematol. 2004. PMID: 15566361 Free article.

9

The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding.

De Cristofaro R, Carotti A, Akhavan S, Palla R, Peyvandi F, Altomare C, Mannucci PM. De Cristofaro R, et al. FEBS J. 2006 Jan;273(1):159-69. doi: 10.1111/j.1742-4658.2005.05052.x. FEBS J. 2006. PMID: 16367756 Free article.

10

Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.

Peyvandi F, Lavoretano S, Palla R, Valsecchi C, Merati G, De Cristofaro R, Rossi E, Mannuccio Mannucci P. Peyvandi F, et al. Among authors: de cristofaro r. Hum Mutat. 2006 Apr;27(4):330-6. doi: 10.1002/humu.20267. Hum Mutat. 2006. PMID: 16453338

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