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Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.
Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman D Jr, Farquhar R, Guo Z, Qiu Y, Brodie AM. Handratta VD, et al. Among authors: vasaitis ts. J Med Chem. 2005 Apr 21;48(8):2972-84. doi: 10.1021/jm040202w. J Med Chem. 2005. PMID: 15828836
CYP17 inhibitors for prostate cancer treatment--an update.
Moreira VM, Salvador JA, Vasaitis TS, Njar VC. Moreira VM, et al. Among authors: vasaitis ts. Curr Med Chem. 2008;15(9):868-99. doi: 10.2174/092986708783955428. Curr Med Chem. 2008. PMID: 18473796 Review.
CYP17 inhibitors for prostate cancer therapy.
Vasaitis TS, Bruno RD, Njar VC. Vasaitis TS, et al. J Steroid Biochem Mol Biol. 2011 May;125(1-2):23-31. doi: 10.1016/j.jsbmb.2010.11.005. Epub 2010 Nov 17. J Steroid Biochem Mol Biol. 2011. PMID: 21092758 Free PMC article. Review.
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AM, Njar VC. Bruno RD, et al. Among authors: vasaitis ts. Steroids. 2011 Nov;76(12):1268-79. doi: 10.1016/j.steroids.2011.06.002. Epub 2011 Jun 24. Steroids. 2011. PMID: 21729712 Free PMC article.
21 results