Dexheimer TS - Search Results

1

Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.

Heald RA, Dexheimer TS, Vankayalapati H, Siddiqui-Jain A, Szabo LZ, Gleason-Guzman MC, Hurley LH. Heald RA, et al. Among authors: dexheimer ts. J Med Chem. 2005 Apr 21;48(8):2993-3004. doi: 10.1021/jm049299c. J Med Chem. 2005. PMID: 15828838

2

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity.

Fellows IM, Schwaebe M, Dexheimer TS, Vankayalapati H, Gleason-Guzman M, Whitten JP, Hurley LH. Fellows IM, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2005 Nov;4(11):1729-39. doi: 10.1158/1535-7163.MCT-05-0183. Mol Cancer Ther. 2005. PMID: 16275994

3

Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.

Dexheimer TS, Sun D, Hurley LH. Dexheimer TS, et al. J Am Chem Soc. 2006 Apr 26;128(16):5404-15. doi: 10.1021/ja0563861. J Am Chem Soc. 2006. PMID: 16620112 Free PMC article.

4

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. Dexheimer TS, et al. Mol Cancer Ther. 2009 May;8(5):1363-77. doi: 10.1158/1535-7163.MCT-08-1093. Epub 2009 May 12. Mol Cancer Ther. 2009. PMID: 19435876 Free PMC article.

5

Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.

Cinelli MA, Morrell A, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. J Med Chem. 2008 Aug 14;51(15):4609-19. doi: 10.1021/jm800259e. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630891 Free PMC article.

6

Design, synthesis, and evaluation of dibenzo[c,h][1,6]naphthyridines as topoisomerase I inhibitors and potential anticancer agents.

Kiselev E, Dexheimer TS, Pommier Y, Cushman M. Kiselev E, et al. Among authors: dexheimer ts. J Med Chem. 2010 Dec 23;53(24):8716-26. doi: 10.1021/jm101048k. Epub 2010 Nov 23. J Med Chem. 2010. PMID: 21090809 Free PMC article.

7

Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors.

Song Y, Shao Z, Dexheimer TS, Scher ES, Pommier Y, Cushman M. Song Y, et al. Among authors: dexheimer ts. J Med Chem. 2010 Mar 11;53(5):1979-89. doi: 10.1021/jm901649x. J Med Chem. 2010. PMID: 20155916 Free PMC article.

8

Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.

Morrell A, Placzek M, Parmley S, Antony S, Dexheimer TS, Pommier Y, Cushman M. Morrell A, et al. Among authors: dexheimer ts. J Med Chem. 2007 Sep 6;50(18):4419-30. doi: 10.1021/jm070361q. Epub 2007 Aug 15. J Med Chem. 2007. PMID: 17696418

9

7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents.

Kiselev E, DeGuire S, Morrell A, Agama K, Dexheimer TS, Pommier Y, Cushman M. Kiselev E, et al. Among authors: dexheimer ts. J Med Chem. 2011 Sep 8;54(17):6106-16. doi: 10.1021/jm200719v. Epub 2011 Aug 8. J Med Chem. 2011. PMID: 21823606 Free PMC article.

10

The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.

Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: dexheimer ts. Bioorg Med Chem. 2010 Aug 1;18(15):5535-52. doi: 10.1016/j.bmc.2010.06.040. Epub 2010 Jun 20. Bioorg Med Chem. 2010. PMID: 20630766 Free PMC article.

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