Gibbs TT - Search Results

1

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Lippa A, et al. Among authors: gibbs tt. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. doi: 10.1073/pnas.0502579102. Epub 2005 May 3. Proc Natl Acad Sci U S A. 2005. PMID: 15870187 Free PMC article. Clinical Trial.

2

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.

Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Berezhnoy D, et al. Among authors: gibbs tt. BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11. BMC Pharmacol. 2008. PMID: 18554397 Free PMC article.

3

The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.

Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. Popik P, et al. Among authors: gibbs tt. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. doi: 10.1124/jpet.106.107201. Epub 2006 Sep 13. J Pharmacol Exp Ther. 2006. PMID: 16971504

4

Molecular and cellular mechanisms of GABA/benzodiazepine-receptor regulation: electrophysiological and biochemical studies.

Farrant M, Gibbs TT, Farb DH. Farrant M, et al. Among authors: gibbs tt. Neurochem Res. 1990 Feb;15(2):175-91. doi: 10.1007/BF00972208. Neurochem Res. 1990. PMID: 2159123 Review. No abstract available.

5

Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels.

Lyons HR, Land MB, Gibbs TT, Farb DH. Lyons HR, et al. Among authors: gibbs tt. J Neurochem. 2001 Sep;78(5):1114-26. doi: 10.1046/j.1471-4159.2001.00501.x. J Neurochem. 2001. PMID: 11553685 Free article.

6

Docking of 1,4-benzodiazepines in the alpha1/gamma2 GABA(A) receptor modulator site.

Berezhnoy D, Gibbs TT, Farb DH. Berezhnoy D, et al. Among authors: gibbs tt. Mol Pharmacol. 2009 Aug;76(2):440-50. doi: 10.1124/mol.109.054650. Epub 2009 May 29. Mol Pharmacol. 2009. PMID: 19483108 Free PMC article.

7

Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.

Malayev A, Gibbs TT, Farb DH. Malayev A, et al. Among authors: gibbs tt. Br J Pharmacol. 2002 Feb;135(4):901-9. doi: 10.1038/sj.bjp.0704543. Br J Pharmacol. 2002. PMID: 11861317 Free PMC article.

8

Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.

Downing SS, Lee YT, Farb DH, Gibbs TT. Downing SS, et al. Among authors: gibbs tt. Br J Pharmacol. 2005 Aug;145(7):894-906. doi: 10.1038/sj.bjp.0706251. Br J Pharmacol. 2005. PMID: 15912137 Free PMC article.

9

Gamma-aminobutyric acidA receptor regulation: chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites.

Friedman L, Gibbs TT, Farb DH. Friedman L, et al. Among authors: gibbs tt. Mol Pharmacol. 1993 Jul;44(1):191-7. Mol Pharmacol. 1993. PMID: 8393520

10

gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture.

Friedman LK, Gibbs TT, Farb DH. Friedman LK, et al. Among authors: gibbs tt. Brain Res. 1996 Jan 22;707(1):100-9. doi: 10.1016/0006-8993(95)01226-5. Brain Res. 1996. PMID: 8866718 Free article.

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