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Page 1
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Lippa A, et al. Among authors: russek sj. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. doi: 10.1073/pnas.0502579102. Epub 2005 May 3. Proc Natl Acad Sci U S A. 2005. PMID: 15870187 Free PMC article. Clinical Trial.
The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. Popik P, et al. Among authors: russek sj. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. doi: 10.1124/jpet.106.107201. Epub 2006 Sep 13. J Pharmacol Exp Ther. 2006. PMID: 16971504
Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression.
Roberts DS, Raol YH, Bandyopadhyay S, Lund IV, Budreck EC, Passini MA, Wolfe JH, Brooks-Kayal AR, Russek SJ. Roberts DS, et al. Among authors: russek sj. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11894-9. doi: 10.1073/pnas.0501434102. Epub 2005 Aug 9. Proc Natl Acad Sci U S A. 2005. PMID: 16091474 Free PMC article.
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.
Kostakis E, Smith C, Jang MK, Martin SC, Richards KG, Russek SJ, Gibbs TT, Farb DH. Kostakis E, et al. Among authors: russek sj. Mol Pharmacol. 2013 Aug;84(2):261-74. doi: 10.1124/mol.113.085696. Epub 2013 May 28. Mol Pharmacol. 2013. PMID: 23716622 Free PMC article.
Sulfated steroids as endogenous neuromodulators.
Gibbs TT, Russek SJ, Farb DH. Gibbs TT, et al. Among authors: russek sj. Pharmacol Biochem Behav. 2006 Aug;84(4):555-67. doi: 10.1016/j.pbb.2006.07.031. Epub 2006 Oct 4. Pharmacol Biochem Behav. 2006. PMID: 17023038 Review.
57 results