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Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.
Mathews PM, Guerra CB, Jiang Y, Grbovic OM, Kao BH, Schmidt SD, Dinakar R, Mercken M, Hille-Rehfeld A, Rohrer J, Mehta P, Cataldo AM, Nixon RA. Mathews PM, et al. Among authors: nixon ra. J Biol Chem. 2002 Feb 15;277(7):5299-307. doi: 10.1074/jbc.M108161200. Epub 2001 Sep 10. J Biol Chem. 2002. PMID: 11551970 Free article.
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production.
Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, Cataldo AM. Grbovic OM, et al. Among authors: nixon ra. J Biol Chem. 2003 Aug 15;278(33):31261-8. doi: 10.1074/jbc.M304122200. Epub 2003 May 20. J Biol Chem. 2003. PMID: 12761223 Free article.
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau LF, Duff K. Noble W, et al. Neuron. 2003 May 22;38(4):555-65. doi: 10.1016/s0896-6273(03)00259-9. Neuron. 2003. PMID: 12765608 Free article.
305 results