Kuwano M - Search Results

1

HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells.

Hirata A, Hosoi F, Miyagawa M, Ueda S, Naito S, Fujii T, Kuwano M, Ono M. Hirata A, et al. Among authors: kuwano m. Cancer Res. 2005 May 15;65(10):4253-60. doi: 10.1158/0008-5472.CAN-04-2748. Cancer Res. 2005. PMID: 15899817

2

ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase.

Hirata A, Ogawa S, Kometani T, Kuwano T, Naito S, Kuwano M, Ono M. Hirata A, et al. Among authors: kuwano m, kuwano t. Cancer Res. 2002 May 1;62(9):2554-60. Cancer Res. 2002. PMID: 11980649

3

Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation.

Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, Fujii T, Kuwano M. Ono M, et al. Among authors: kuwano m. Mol Cancer Ther. 2004 Apr;3(4):465-72. Mol Cancer Ther. 2004. PMID: 15078990

4

Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib ('Iressa', ZD1839).

Hirata A, Uehara H, Izumi K, Naito S, Kuwano M, Ono M. Hirata A, et al. Among authors: kuwano m. Cancer Sci. 2004 Jul;95(7):614-8. doi: 10.1111/j.1349-7006.2004.tb02496.x. Cancer Sci. 2004. PMID: 15245600 Free PMC article.

5

PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib.

Ueda S, Basaki Y, Yoshie M, Ogawa K, Sakisaka S, Kuwano M, Ono M. Ueda S, et al. Among authors: kuwano m. Cancer Res. 2006 May 15;66(10):5346-53. doi: 10.1158/0008-5472.CAN-05-3684. Cancer Res. 2006. PMID: 16707461

6

Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs.

Ono M, Kuwano M. Ono M, et al. Among authors: kuwano m. Clin Cancer Res. 2006 Dec 15;12(24):7242-51. doi: 10.1158/1078-0432.CCR-06-0646. Clin Cancer Res. 2006. PMID: 17189395 Review.

7

N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression.

Hosoi F, Izumi H, Kawahara A, Murakami Y, Kinoshita H, Kage M, Nishio K, Kohno K, Kuwano M, Ono M. Hosoi F, et al. Among authors: kuwano m. Cancer Res. 2009 Jun 15;69(12):4983-91. doi: 10.1158/0008-5472.CAN-08-4882. Epub 2009 Jun 2. Cancer Res. 2009. PMID: 19491262

8

Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations.

Yamamoto C, Basaki Y, Kawahara A, Nakashima K, Kage M, Izumi H, Kohno K, Uramoto H, Yasumoto K, Kuwano M, Ono M. Yamamoto C, et al. Among authors: kuwano m. Cancer Res. 2010 Nov 1;70(21):8715-25. doi: 10.1158/0008-5472.CAN-10-0043. Epub 2010 Oct 19. Cancer Res. 2010. PMID: 20959484

9

The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway.

Watari K, Nakamura M, Fukunaga Y, Furuno A, Shibata T, Kawahara A, Hosoi F, Kuwano T, Kuwano M, Ono M. Watari K, et al. Among authors: kuwano m, kuwano t. Int J Cancer. 2012 Jul 15;131(2):310-21. doi: 10.1002/ijc.26356. Epub 2011 Sep 14. Int J Cancer. 2012. PMID: 21826646

10

[Tumor angiogenesis and tumor angiogenesis inhibitors].

Ono M, Kuwano M. Ono M, et al. Among authors: kuwano m. Gan To Kagaku Ryoho. 2001 May;28(5):584-90. Gan To Kagaku Ryoho. 2001. PMID: 11383205 Review. Japanese.

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