Spielmann HP - Search Results

1

Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.

Subramanian T, Wang Z, Troutman JM, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Org Lett. 2005 May 26;7(11):2109-12. doi: 10.1021/ol050386o. Org Lett. 2005. PMID: 15901146

2

Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.

Chehade KA, Kiegiel K, Isaacs RJ, Pickett JS, Bowers KE, Fierke CA, Andres DA, Spielmann HP. Chehade KA, et al. Among authors: spielmann hp. J Am Chem Soc. 2002 Jul 17;124(28):8206-19. doi: 10.1021/ja0124717. J Am Chem Soc. 2002. PMID: 12105898

3

Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate.

Troutman JM, Chehade KA, Kiegiel K, Andres DA, Spielmann HP. Troutman JM, et al. Among authors: spielmann hp. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4979-82. doi: 10.1016/j.bmcl.2004.07.017. Bioorg Med Chem Lett. 2004. PMID: 15341963

4

Tools to analyze protein farnesylation in cells.

Troutman JM, Roberts MJ, Andres DA, Spielmann HP. Troutman JM, et al. Among authors: spielmann hp. Bioconjug Chem. 2005 Sep-Oct;16(5):1209-17. doi: 10.1021/bc050068+. Bioconjug Chem. 2005. PMID: 16173800

5

Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.

Roberts MJ, Troutman JM, Chehade KA, Cha HC, Kao JP, Huang X, Zhan CG, Peterson YK, Subramanian T, Kamalakkannan S, Andres DA, Spielmann HP. Roberts MJ, et al. Among authors: spielmann hp. Biochemistry. 2006 Dec 26;45(51):15862-72. doi: 10.1021/bi061704+. Epub 2006 Dec 6. Biochemistry. 2006. PMID: 17176109

6

Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.

Troutman JM, Subramanian T, Andres DA, Spielmann HP. Troutman JM, et al. Among authors: spielmann hp. Biochemistry. 2007 Oct 9;46(40):11310-21. doi: 10.1021/bi700516m. Epub 2007 Sep 14. Biochemistry. 2007. PMID: 17854205

7

Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release.

Troutman JM, Andres DA, Spielmann HP. Troutman JM, et al. Among authors: spielmann hp. Biochemistry. 2007 Oct 9;46(40):11299-309. doi: 10.1021/bi700513n. Epub 2007 Sep 18. Biochemistry. 2007. PMID: 17877368

8

Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.

Subramanian T, Liu S, Troutman JM, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Chembiochem. 2008 Nov 24;9(17):2872-82. doi: 10.1002/cbic.200800248. Chembiochem. 2008. PMID: 18985644 Free PMC article.

9

Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Biochemistry. 2012 Oct 16;51(41):8307-19. doi: 10.1021/bi3011362. Epub 2012 Oct 2. Biochemistry. 2012. PMID: 22989235 Free PMC article.

10

Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.

Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Rising KA, et al. Among authors: spielmann hp. ACS Chem Biol. 2015 Jul 17;10(7):1729-36. doi: 10.1021/acschembio.5b00145. Epub 2015 May 4. ACS Chem Biol. 2015. PMID: 25897591 Free PMC article.

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