Townsend LB - Search Results

1

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Lorenzi PL, et al. Among authors: townsend lb. J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. doi: 10.1124/jpet.104.082412. Epub 2005 May 18. J Pharmacol Exp Ther. 2005. PMID: 15901797

2

Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus.

Krosky PM, Borysko KZ, Nassiri MR, Devivar RV, Ptak RG, Davis MG, Biron KK, Townsend LB, Drach JC. Krosky PM, et al. Among authors: townsend lb. Antimicrob Agents Chemother. 2002 Feb;46(2):478-86. doi: 10.1128/AAC.46.2.478-486.2002. Antimicrob Agents Chemother. 2002. PMID: 11796361 Free PMC article.

3

Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides.

Komazin G, Townsend LB, Drach JC. Komazin G, et al. Among authors: townsend lb. J Virol. 2004 Jan;78(2):710-5. doi: 10.1128/jvi.78.2.710-715.2004. J Virol. 2004. PMID: 14694102 Free PMC article.

4

Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Chien TC, Saluja SS, Drach JC, Townsend LB. Chien TC, et al. Among authors: townsend lb. J Med Chem. 2004 Nov 4;47(23):5743-52. doi: 10.1021/jm040016q. J Med Chem. 2004. PMID: 15509173

5

Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.

Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Song X, et al. Among authors: townsend lb. J Med Chem. 2005 Feb 24;48(4):1274-7. doi: 10.1021/jm049450i. J Med Chem. 2005. PMID: 15715497

6

N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL. Lorenzi PL, et al. Among authors: townsend lb. Drug Metab Dispos. 2006 Jun;34(6):1070-7. doi: 10.1124/dmd.105.009209. Epub 2006 Mar 24. Drug Metab Dispos. 2006. PMID: 16565170

7

Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles.

Devivar RV, Kawashima E, Revankar GR, Breitenbach JM, Kreske ED, Drach JC, Townsend LB. Devivar RV, et al. Among authors: townsend lb. J Med Chem. 1994 Sep 2;37(18):2942-9. doi: 10.1021/jm00044a015. J Med Chem. 1994. PMID: 8071942

8

Design, synthesis, and antiviral evaluation of 2-substituted 4,5-dichloro- and 4,6-dichloro-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections.

Zou R, Drach JC, Townsend LB. Zou R, et al. Among authors: townsend lb. J Med Chem. 1997 Feb 28;40(5):802-10. doi: 10.1021/jm960533b. J Med Chem. 1997. PMID: 9057867

9

Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB).

Chen JJ, Wei Y, Drach JC, Townsend LB. Chen JJ, et al. Among authors: townsend lb. J Med Chem. 2000 Jun 15;43(12):2449-56. doi: 10.1021/jm990320x. J Med Chem. 2000. PMID: 10882372

10

Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.

Gudmundsson KS, Freeman GA, Drach JC, Townsend LB. Gudmundsson KS, et al. Among authors: townsend lb. J Med Chem. 2000 Jun 15;43(12):2473-8. doi: 10.1021/jm990219s. J Med Chem. 2000. PMID: 10882375

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