Xiao X - Search Results

1

Dihydroindenoisoquinolines function as prodrugs of indenoisoquinolines.

Xiao X, Miao ZH, Antony S, Pommier Y, Cushman M. Xiao X, et al. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2795-8. doi: 10.1016/j.bmcl.2005.03.101. Bioorg Med Chem Lett. 2005. PMID: 15911256

2

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Fox BM, et al. Among authors: xiao x. J Med Chem. 2003 Jul 17;46(15):3275-82. doi: 10.1021/jm0300476. J Med Chem. 2003. PMID: 12852757

3

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. Among authors: xiao x. J Med Chem. 2003 Dec 18;46(26):5712-24. doi: 10.1021/jm030313f. J Med Chem. 2003. PMID: 14667224

4

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.

Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Xiao X, et al. Bioorg Med Chem. 2004 Oct 1;12(19):5147-60. doi: 10.1016/j.bmc.2004.07.027. Bioorg Med Chem. 2004. PMID: 15351398

5

Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.

Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Xiao X, et al. J Org Chem. 2004 Oct 29;69(22):7495-501. doi: 10.1021/jo048808f. J Org Chem. 2004. PMID: 15497974

6

On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.

Xiao X, Antony S, Pommier Y, Cushman M. Xiao X, et al. J Med Chem. 2005 May 5;48(9):3231-8. doi: 10.1021/jm050017y. J Med Chem. 2005. PMID: 15857129

7

Total synthesis and biological evaluation of 22-hydroxyacuminatine.

Xiao X, Antony S, Pommier Y, Cushman M. Xiao X, et al. J Med Chem. 2006 Feb 23;49(4):1408-12. doi: 10.1021/jm051116e. J Med Chem. 2006. PMID: 16480276 Free PMC article.

8

An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes.

Xiao X, Cushman M. Xiao X, et al. J Am Chem Soc. 2005 Jul 20;127(28):9960-1. doi: 10.1021/ja042485n. J Am Chem Soc. 2005. PMID: 16011334 Free PMC article.

9

A Facile method to transform trans-4-carboxy-3,4-dihydro-3-phenyl- 1(2H)-isoquinolones to indeno[1,2-c]isoquinolines.

Xiao X, Cushman M. Xiao X, et al. J Org Chem. 2005 Aug 5;70(16):6496-8. doi: 10.1021/jo050831t. J Org Chem. 2005. PMID: 16050715 Free PMC article.

10

Effect of E-ring modifications in camptothecin on topoisomerase I inhibition: a quantum mechanics treatment.

Xiao X, Cushman M. Xiao X, et al. J Org Chem. 2005 Nov 11;70(23):9584-7. doi: 10.1021/jo0513360. J Org Chem. 2005. PMID: 16268636

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