Osborne MR - Search Results

1

Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.

Phillips DH, Hewer A, Osborne MR, Cole KJ, Churchill C, Arlt VM. Phillips DH, et al. Among authors: osborne mr. Mutagenesis. 2005 Jul;20(4):297-303. doi: 10.1093/mutage/gei038. Epub 2005 May 31. Mutagenesis. 2005. PMID: 15928012

2

Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells.

Osborne MR, Hewer A, Phillips DH. Osborne MR, et al. Chem Res Toxicol. 2004 May;17(5):697-701. doi: 10.1021/tx049957w. Chem Res Toxicol. 2004. PMID: 15144227

3

Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.

Schild LJ, Phillips DH, Osborne MR, Hewer A, Beland FA, Churchwell MI, Brown K, Gaskell M, Wright E, Poirier MC. Schild LJ, et al. Among authors: osborne mr. Mutagenesis. 2005 Mar;20(2):115-24. doi: 10.1093/mutage/gei015. Epub 2005 Mar 8. Mutagenesis. 2005. PMID: 15755801

4

DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats.

Arlt VM, Sorg BL, Osborne M, Hewer A, Seidel A, Schmeiser HH, Phillips DH. Arlt VM, et al. Biochem Biophys Res Commun. 2003 Jan 3;300(1):107-14. doi: 10.1016/s0006-291x(02)02789-4. Biochem Biophys Res Commun. 2003. PMID: 12480528

5

4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.

Osborne MR, Davis W, Hewer AJ, Hardcastle IR, Phillips DH. Osborne MR, et al. Chem Res Toxicol. 1999 Feb;12(2):151-8. doi: 10.1021/tx980187w. Chem Res Toxicol. 1999. PMID: 10027792

6

Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.

Osborne MR, Hewer A, Davis W, Strain AJ, Keogh A, Hardcastle IR, Phillips DH. Osborne MR, et al. Carcinogenesis. 1999 Feb;20(2):293-7. doi: 10.1093/carcin/20.2.293. Carcinogenesis. 1999. PMID: 10069467

7

N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.

Phillips DH, Hewer A, Horton MN, Cole KJ, Carmichael PL, Davis W, Osborne MR. Phillips DH, et al. Among authors: osborne mr. Carcinogenesis. 1999 Oct;20(10):2003-9. doi: 10.1093/carcin/20.10.2003. Carcinogenesis. 1999. PMID: 10506117

8

Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells.

Osborne MR, Hewer A, Phillips DH. Osborne MR, et al. Chem Res Toxicol. 2001 Jul;14(7):888-93. doi: 10.1021/tx010027b. Chem Res Toxicol. 2001. PMID: 11453736

9

Interaction of omeprazole with DNA in rat tissues.

Phillips DH, Hewer A, Osborne MR. Phillips DH, et al. Among authors: osborne mr. Mutagenesis. 1992 Jul;7(4):277-83. doi: 10.1093/mutage/7.4.277. Mutagenesis. 1992. PMID: 1518411

10

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

Arlt VM, Stiborova M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martinek V, Sopko B, Wolf CR, Schmeiser HH, Phillips DH. Arlt VM, et al. Among authors: osborne mr. Cancer Res. 2005 Apr 1;65(7):2644-52. doi: 10.1158/0008-5472.CAN-04-3544. Cancer Res. 2005. PMID: 15805261

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