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A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4.
Asensio JL, Hidalgo A, Bastida A, Torrado M, Corzana F, Chiara JL, García-Junceda E, Cañada J, Jiménez-Barbero J. Asensio JL, et al. Among authors: torrado m. J Am Chem Soc. 2005 Jun 15;127(23):8278-9. doi: 10.1021/ja051722z. J Am Chem Soc. 2005. PMID: 15941249 Free article.
NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): the pattern of OH/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation.
Revuelta J, Vacas T, Torrado M, Corzana F, Gonzalez C, Jiménez-Barbero J, Menendez M, Bastida A, Asensio JL. Revuelta J, et al. Among authors: torrado m. J Am Chem Soc. 2008 Apr 16;130(15):5086-103. doi: 10.1021/ja076835s. Epub 2008 Mar 26. J Am Chem Soc. 2008. PMID: 18366171
CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation.
Zhong Y, Paudel BP, Ryan DP, Low JKK, Franck C, Patel K, Bedward MJ, Torrado M, Payne RJ, van Oijen AM, Mackay JP. Zhong Y, et al. Among authors: torrado m. Nat Commun. 2020 Mar 23;11(1):1519. doi: 10.1038/s41467-020-15183-2. Nat Commun. 2020. PMID: 32251276 Free PMC article.
The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture.
Low JKK, Silva APG, Sharifi Tabar M, Torrado M, Webb SR, Parker BL, Sana M, Smits C, Schmidberger JW, Brillault L, Jackman MJ, Williams DC Jr, Blobel GA, Hake SB, Shepherd NE, Landsberg MJ, Mackay JP. Low JKK, et al. Among authors: torrado m. Cell Rep. 2020 Dec 1;33(9):108450. doi: 10.1016/j.celrep.2020.108450. Cell Rep. 2020. PMID: 33264611 Free PMC article.
108 results