Bottomley SP - Search Results

1

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway.

Cappai R, Leck SL, Tew DJ, Williamson NA, Smith DP, Galatis D, Sharples RA, Curtain CC, Ali FE, Cherny RA, Culvenor JG, Bottomley SP, Masters CL, Barnham KJ, Hill AF. Cappai R, et al. Among authors: bottomley sp. FASEB J. 2005 Aug;19(10):1377-9. doi: 10.1096/fj.04-3437fje. Epub 2005 Jun 9. FASEB J. 2005. PMID: 15946991

2

Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein.

Smith DP, Tew DJ, Hill AF, Bottomley SP, Masters CL, Barnham KJ, Cappai R. Smith DP, et al. Among authors: bottomley sp. Biochemistry. 2008 Feb 5;47(5):1425-34. doi: 10.1021/bi701522m. Epub 2008 Jan 8. Biochemistry. 2008. PMID: 18179253

3

Conformational behavior and aggregation of ataxin-3 in SDS.

Saunders HM, Hughes VA, Cappai R, Bottomley SP. Saunders HM, et al. Among authors: bottomley sp. PLoS One. 2013 Jul 22;8(7):e69416. doi: 10.1371/journal.pone.0069416. Print 2013. PLoS One. 2013. PMID: 23894474 Free PMC article.

4

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide.

Tew DJ, Bottomley SP, Smith DP, Ciccotosto GD, Babon J, Hinds MG, Masters CL, Cappai R, Barnham KJ. Tew DJ, et al. Among authors: bottomley sp. Biophys J. 2008 Apr 1;94(7):2752-66. doi: 10.1529/biophysj.107.119909. Epub 2007 Dec 7. Biophys J. 2008. PMID: 18065467 Free PMC article.

5

The citrate ion increases the conformational stability of alpha(1)-antitrypsin.

Bottomley SP, Tew DJ. Bottomley SP, et al. Biochim Biophys Acta. 2000 Aug 31;1481(1):11-7. doi: 10.1016/s0167-4838(00)00118-7. Biochim Biophys Acta. 2000. PMID: 10962087

6

Probing the equilibrium denaturation of the serpin alpha(1)-antitrypsin with single tryptophan mutants; evidence for structure in the urea unfolded state.

Tew DJ, Bottomley SP. Tew DJ, et al. Among authors: bottomley sp. J Mol Biol. 2001 Nov 9;313(5):1161-9. doi: 10.1006/jmbi.2001.5104. J Mol Biol. 2001. PMID: 11700071

7

Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition.

Tew DJ, Bottomley SP. Tew DJ, et al. Among authors: bottomley sp. FEBS Lett. 2001 Apr 6;494(1-2):30-3. doi: 10.1016/s0014-5793(01)02305-5. FEBS Lett. 2001. PMID: 11297729 Free article.

8

Prevention of polymerization of M and Z alpha1-Antitrypsin (alpha1-AT) with trimethylamine N-oxide. Implications for the treatment of alpha1-at deficiency.

Devlin GL, Parfrey H, Tew DJ, Lomas DA, Bottomley SP. Devlin GL, et al. Among authors: bottomley sp. Am J Respir Cell Mol Biol. 2001 Jun;24(6):727-32. doi: 10.1165/ajrcmb.24.6.4407. Am J Respir Cell Mol Biol. 2001. PMID: 11415938

9

The role of strand 1 of the C beta-sheet in the structure and function of alpha(1)-antitrypsin.

Bottomley SP, Lawrenson ID, Tew D, Dai W, Whisstock JC, Pike RN. Bottomley SP, et al. Protein Sci. 2001 Dec;10(12):2518-24. doi: 10.1110/ps.ps.24101. Protein Sci. 2001. PMID: 11714919 Free PMC article.

10

Thrombin, a survival factor for cultured myoblasts.

Chinni C, de Niese MR, Tew DJ, Jenkins AL, Bottomley SP, Mackie EJ. Chinni C, et al. Among authors: bottomley sp. J Biol Chem. 1999 Apr 2;274(14):9169-74. doi: 10.1074/jbc.274.14.9169. J Biol Chem. 1999. PMID: 10092588 Free article.

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