Haffner C - Search Results

1

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C. Krawitz P, et al. Among authors: haffner c. J Biol Chem. 2005 Nov 25;280(47):39515-23. doi: 10.1074/jbc.M501645200. Epub 2005 Jul 5. J Biol Chem. 2005. PMID: 15998642 Free article.

2

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C. Fluhrer R, et al. Among authors: haffner c. Nat Cell Biol. 2006 Aug;8(8):894-6. doi: 10.1038/ncb1450. Epub 2006 Jul 9. Nat Cell Biol. 2006. PMID: 16829951

3

The biochemical and genetic odyssey to the function of a nicastrin-like protein.

Haffner C, Haass C. Haffner C, et al. Neurodegener Dis. 2004;1(4-5):192-5. doi: 10.1159/000080985. Neurodegener Dis. 2004. PMID: 16908989 Free article. Review.

4

Cellular functions of gamma-secretase-related proteins.

Haffner C, Haass C. Haffner C, et al. Neurodegener Dis. 2006;3(4-5):284-9. doi: 10.1159/000095268. Neurodegener Dis. 2006. PMID: 17047369 Review.

5

The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.

Haffner C, Dettmer U, Weiler T, Haass C. Haffner C, et al. J Biol Chem. 2007 Apr 6;282(14):10632-8. doi: 10.1074/jbc.M611033200. Epub 2007 Jan 29. J Biol Chem. 2007. PMID: 17261586 Free article.

6

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.

Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Dettmer U, et al. Among authors: haffner c. J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10. J Biol Chem. 2010. PMID: 20538592 Free PMC article.

7

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. Haffner C, et al. EMBO J. 2004 Aug 4;23(15):3041-50. doi: 10.1038/sj.emboj.7600307. Epub 2004 Jul 15. EMBO J. 2004. PMID: 15257293 Free PMC article.

8

Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.

Zellner A, Müller SA, Lindner B, Beaufort N, Rozemuller AJM, Arzberger T, Gassen NC, Lichtenthaler SF, Kuster B, Haffner C, Dichgans M. Zellner A, et al. Among authors: haffner c. Acta Neuropathol Commun. 2022 Jan 24;10(1):6. doi: 10.1186/s40478-021-01303-6. Acta Neuropathol Commun. 2022. PMID: 35074002 Free PMC article.

9

CADASIL brain vessels show a HTRA1 loss-of-function profile.

Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C. Zellner A, et al. Among authors: haffner c. Acta Neuropathol. 2018 Jul;136(1):111-125. doi: 10.1007/s00401-018-1853-8. Epub 2018 May 3. Acta Neuropathol. 2018. PMID: 29725820

10

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M. Beaufort N, et al. Among authors: haffner c. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16496-501. doi: 10.1073/pnas.1418087111. Epub 2014 Nov 4. Proc Natl Acad Sci U S A. 2014. PMID: 25369932 Free PMC article.

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