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Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Glenn MP, et al. Among authors: sebti sm. Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674. Angew Chem Int Ed Engl. 2005. PMID: 16007716 No abstract available.
Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Glenn MP, et al. Among authors: sebti sm. J Med Chem. 2006 Sep 21;49(19):5710-27. doi: 10.1021/jm060081v. J Med Chem. 2006. PMID: 16970397 Free PMC article.
Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Fletcher S, et al. Among authors: sebti sm. J Med Chem. 2008 Sep 11;51(17):5176-97. doi: 10.1021/jm800113p. Epub 2008 Aug 8. J Med Chem. 2008. PMID: 18686940 Free PMC article.
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Yin H, Lee GI, Park HS, Payne GA, Rodriguez JM, Sebti SM, Hamilton AD. Yin H, et al. Among authors: sebti sm. Angew Chem Int Ed Engl. 2005 Apr 29;44(18):2704-2707. doi: 10.1002/anie.200462316. Angew Chem Int Ed Engl. 2005. PMID: 15765497 No abstract available.
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Fletcher S, et al. Among authors: sebti sm. J Med Chem. 2010 Oct 14;53(19):6867-88. doi: 10.1021/jm1001748. J Med Chem. 2010. PMID: 20822181 Free PMC article.
293 results