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3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.
Huang LS, Sun G, Cobessi D, Wang AC, Shen JT, Tung EY, Anderson VE, Berry EA. Huang LS, et al. Among authors: cobessi d. J Biol Chem. 2006 Mar 3;281(9):5965-72. doi: 10.1074/jbc.M511270200. Epub 2005 Dec 21. J Biol Chem. 2006. PMID: 16371358 Free PMC article.
38 results