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Page 1
Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Olson S, Aster SD, Brown K, Carbin L, Graham DW, Hermanowski-Vosatka A, LeGrand CB, Mundt SS, Robbins MA, Schaeffer JM, Slossberg LH, Szymonifka MJ, Thieringer R, Wright SD, Balkovec JM. Olson S, et al. Among authors: legrand cb. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4359-62. doi: 10.1016/j.bmcl.2005.06.040. Bioorg Med Chem Lett. 2005. PMID: 16039856
Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
Gu X, Dragovic J, Koo GC, Koprak SL, LeGrand C, Mundt SS, Shah K, Springer MS, Tan EY, Thieringer R, Hermanowski-Vosatka A, Zokian HJ, Balkovec JM, Waddell ST. Gu X, et al. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5266-9. doi: 10.1016/j.bmcl.2005.08.052. Epub 2005 Sep 26. Bioorg Med Chem Lett. 2005. PMID: 16185866
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.
Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hernandez M, Koo GC, Le Grand CB, Li Z, Metzger JM, Mundt SS, Noonan H, Nunes CN, Olson SH, Pikounis B, Ren N, Robertson N, Schaeffer JM, Shah K, Springer MS, Strack AM, Strowski M, Wu K, Wu T, Xiao J, Zhang BB, Wright SD, Thieringer R. Hermanowski-Vosatka A, et al. J Exp Med. 2005 Aug 15;202(4):517-27. doi: 10.1084/jem.20050119. J Exp Med. 2005. PMID: 16103409 Free PMC article.
High-throughput simultaneous analysis of RNA, protein, and lipid biomarkers in heterogeneous tissue samples.
Reiser V, Smith RC, Xue J, Kurtz MM, Liu R, Legrand C, He X, Yu X, Wong P, Hinchcliffe JS, Tanen MR, Lazar G, Zieba R, Ichetovkin M, Chen Z, O'Neill EA, Tanaka WK, Marton MJ, Liao J, Morris M, Hailman E, Tokiwa GY, Plump AS. Reiser V, et al. Clin Chem. 2011 Nov;57(11):1545-55. doi: 10.1373/clinchem.2010.157743. Epub 2011 Sep 13. Clin Chem. 2011. PMID: 21914789
Glucose homeostasis in magnesium-deficient rats.
Legrand C, Okitolonda W, Pottier AM, Lederer J, Henquin JC. Legrand C, et al. Metabolism. 1987 Feb;36(2):160-4. doi: 10.1016/0026-0495(87)90011-4. Metabolism. 1987. PMID: 3543614