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Activation of protein kinase G is sufficient to induce apoptosis and inhibit cell migration in colon cancer cells.
Deguchi A, Thompson WJ, Weinstein IB. Deguchi A, et al. Cancer Res. 2004 Jun 1;64(11):3966-73. doi: 10.1158/0008-5472.CAN-03-3740. Cancer Res. 2004. PMID: 15173009
To directly examine the effects of PKG on cell growth and apoptosis, we generated a series of mutants of PKG Ialpha: PKG IalphaS65D, a constitutively activated point mutant; PKG IalphaDelta, a constitutively activated N-terminal truncated mutant; and PKG Ialp …
To directly examine the effects of PKG on cell growth and apoptosis, we generated a series of mutants of PKG Ialpha: PKG IalphaS65D, …
196 results