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Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase.
Mann PA, Parmegiani RM, Wei SQ, Mendrick CA, Li X, Loebenberg D, DiDomenico B, Hare RS, Walker SS, McNicholas PM. Mann PA, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2003 Feb;47(2):577-81. doi: 10.1128/AAC.47.2.577-581.2003. Antimicrob Agents Chemother. 2003. PMID: 12543662 Free PMC article.
Effect of granulocyte colony-stimulating factor combination therapy on efficacy of posaconazole (SCH56592) in an inhalation model of murine pulmonary aspergillosis.
Patera AC, Menzel F, Jackson C, Brieland JK, Halpern J, Hare R, Cacciapuoti A, Loebenberg D. Patera AC, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2004 Aug;48(8):3154-8. doi: 10.1128/AAC.48.8.3154-3158.2004. Antimicrob Agents Chemother. 2004. PMID: 15273138 Free PMC article.
Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.
Munayyer HK, Mann PA, Chau AS, Yarosh-Tomaine T, Greene JR, Hare RS, Heimark L, Palermo RE, Loebenberg D, McNicholas PM. Munayyer HK, et al. Among authors: loebenberg d. Antimicrob Agents Chemother. 2004 Oct;48(10):3690-6. doi: 10.1128/AAC.48.10.3690-3696.2004. Antimicrob Agents Chemother. 2004. PMID: 15388421 Free PMC article.
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
Bennett F, Saksena AK, Lovey RG, Liu YT, Patel NM, Pinto P, Pike R, Jao E, Girijavallabhan VM, Ganguly AK, Loebenberg D, Wang H, Cacciapuoti A, Moss E, Menzel F, Hare RS, Nomeir A. Bennett F, et al. Among authors: loebenberg d. Bioorg Med Chem Lett. 2006 Jan 1;16(1):186-90. doi: 10.1016/j.bmcl.2005.09.031. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16260134
102 results