Gómez-Lechón MJ - Search Results

1

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach.

Castell JV, Donato MT, Gómez-Lechón MJ. Castell JV, et al. Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:189-204. doi: 10.1016/j.etp.2005.05.008. Exp Toxicol Pathol. 2005. PMID: 16092727 Review.

2

Human hepatic cell cultures: in vitro and in vivo drug metabolism.

Gómez-Lechón MJ, Donato T, Ponsoda X, Castell JV. Gómez-Lechón MJ, et al. Altern Lab Anim. 2003 May-Jun;31(3):257-65. doi: 10.1177/026119290303100307. Altern Lab Anim. 2003. PMID: 15612868

3

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies.

Castell JV, Jover R, Martínez-Jiménez CP, Gómez-Lechón MJ. Castell JV, et al. Expert Opin Drug Metab Toxicol. 2006 Apr;2(2):183-212. doi: 10.1517/17425255.2.2.183. Expert Opin Drug Metab Toxicol. 2006. PMID: 16866607 Review.

4

Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.

Gómez-Lechón MJ, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Chem Biol Interact. 2007 May 20;168(1):30-50. doi: 10.1016/j.cbi.2006.10.013. Epub 2006 Nov 28. Chem Biol Interact. 2007. PMID: 17134688 Review.

5

A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.

Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ. Lahoz A, et al. Rapid Commun Mass Spectrom. 2008;22(2):240-4. doi: 10.1002/rcm.3359. Rapid Commun Mass Spectrom. 2008. PMID: 18088071

6

An update on metabolism studies using human hepatocytes in primary culture.

Gómez-Lechón MJ, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Expert Opin Drug Metab Toxicol. 2008 Jul;4(7):837-54. doi: 10.1517/17425255.4.7.837. Expert Opin Drug Metab Toxicol. 2008. PMID: 18624674 Review.

7

Evaluation of cytochrome P450 activities in human hepatocytes in vitro.

Gómez-Lechón MJ, Lahoz A, Castell JV, Donato MT. Gómez-Lechón MJ, et al. Methods Mol Biol. 2012;806:87-97. doi: 10.1007/978-1-61779-367-7_7. Methods Mol Biol. 2012. PMID: 22057447

8

Can hepatoma cell lines be redifferentiated to be used in drug metabolism studies?

Martínez-Jiménez CP, Jover R, Gómez-Lechón MJ, Castell JV. Martínez-Jiménez CP, et al. Altern Lab Anim. 2004 Jun;32 Suppl 1A:65-74. doi: 10.1177/026119290403201s11. Altern Lab Anim. 2004. PMID: 23577436

9

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes.

Pérez G, Tabares B, Jover R, Gómez-Lechón MJ, Castell JV. Pérez G, et al. Toxicol In Vitro. 2003 Oct-Dec;17(5-6):643-9. doi: 10.1016/s0887-2333(03)00109-7. Toxicol In Vitro. 2003. PMID: 14599457

10

Diclofenac induces apoptosis in hepatocytes.

Gómez-Lechón MJ, Ponsoda X, O'Connor E, Donato T, Jover R, Castell JV. Gómez-Lechón MJ, et al. Toxicol In Vitro. 2003 Oct-Dec;17(5-6):675-80. doi: 10.1016/s0887-2333(03)00105-x. Toxicol In Vitro. 2003. PMID: 14599462

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