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266 results

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Page 1
Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.
Büttelmann B, Peters JU, Ceccarelli S, Kolczewski S, Vieira E, Prinssen EP, Spooren W, Schuler F, Huwyler J, Porter RH, Jaeschke G. Büttelmann B, et al. Among authors: huwyler j. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7. doi: 10.1016/j.bmcl.2005.12.088. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439120
Rational design, synthesis, and structure-activity relationship of benzoxazolones: new potent mglu5 receptor antagonists based on the fenobam structure.
Ceccarelli SM, Jaeschke G, Buettelmann B, Huwyler J, Kolczewski S, Peters JU, Prinssen E, Porter R, Spooren W, Vieira E. Ceccarelli SM, et al. Among authors: huwyler j. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1302-6. doi: 10.1016/j.bmcl.2006.12.006. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17189691
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Jaeschke G, Porter R, Büttelmann B, Ceccarelli SM, Guba W, Kuhn B, Kolczewski S, Huwyler J, Mutel V, Peters JU, Ballard T, Prinssen E, Vieira E, Wichmann J, Spooren W. Jaeschke G, et al. Among authors: huwyler j. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1307-11. doi: 10.1016/j.bmcl.2006.12.033. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17196387
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists.
Woltering TJ, Wichmann J, Goetschi E, Adam G, Kew JN, Knoflach F, Ballard TM, Huwyler J, Mutel V, Gatti S. Woltering TJ, et al. Among authors: huwyler j. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2725-9. doi: 10.1016/j.bmcl.2008.02.076. Epub 2008 Mar 5. Bioorg Med Chem Lett. 2008. PMID: 18374569
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.
Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, Kolb Y, Marcuz A, Huwyler J, Nakagawa T, Porter RH, Thomas AW, Wettstein JG, Sleight AJ, Spooren W, Prinssen EP. Malherbe P, et al. Among authors: huwyler j. Br J Pharmacol. 2008 Jun;154(4):797-811. doi: 10.1038/bjp.2008.135. Epub 2008 Apr 21. Br J Pharmacol. 2008. PMID: 18536733 Free PMC article.
5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
Pierson PD, Fettes A, Freichel C, Gatti-McArthur S, Hertel C, Huwyler J, Mohr P, Nakagawa T, Nettekoven M, Plancher JM, Raab S, Richter H, Roche O, Rodríguez Sarmiento RM, Schmitt M, Schuler F, Takahashi T, Taylor S, Ullmer C, Wiegand R. Pierson PD, et al. Among authors: huwyler j. J Med Chem. 2009 Jul 9;52(13):3855-68. doi: 10.1021/jm900409x. J Med Chem. 2009. PMID: 19456097
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists.
Woltering TJ, Wichmann J, Goetschi E, Knoflach F, Ballard TM, Huwyler J, Gatti S. Woltering TJ, et al. Among authors: huwyler j. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6969-74. doi: 10.1016/j.bmcl.2010.09.125. Epub 2010 Oct 21. Bioorg Med Chem Lett. 2010. PMID: 20971004
266 results