Plückthun A - Search Results

1

Protein PEGylation decreases observed target association rates via a dual blocking mechanism.

Kubetzko S, Sarkar CA, Plückthun A. Kubetzko S, et al. Among authors: pluckthun a. Mol Pharmacol. 2005 Nov;68(5):1439-54. doi: 10.1124/mol.105.014910. Epub 2005 Aug 12. Mol Pharmacol. 2005. PMID: 16099846

2

Viral escape at the molecular level explained by quantitative T-cell receptor/peptide/MHC interactions and the crystal structure of a peptide/MHC complex.

Tissot AC, Ciatto C, Mittl PR, Grütter MG, Plückthun A. Tissot AC, et al. Among authors: pluckthun a. J Mol Biol. 2000 Sep 29;302(4):873-85. doi: 10.1006/jmbi.2000.4501. J Mol Biol. 2000. PMID: 10993729

3

Tumor targeting of mono-, di-, and tetravalent anti-p185(HER-2) miniantibodies multimerized by self-associating peptides.

Willuda J, Kubetzko S, Waibel R, Schubiger PA, Zangemeister-Wittke U, Plückthun A. Willuda J, et al. Among authors: pluckthun a. J Biol Chem. 2001 Apr 27;276(17):14385-92. doi: 10.1074/jbc.M011669200. Epub 2001 Jan 22. J Biol Chem. 2001. PMID: 11278961 Free article.

4

A recombinant immunotoxin derived from a humanized epithelial cell adhesion molecule-specific single-chain antibody fragment has potent and selective antitumor activity.

Di Paolo C, Willuda J, Kubetzko S, Lauffer I, Tschudi D, Waibel R, Plückthun A, Stahel RA, Zangemeister-Wittke U. Di Paolo C, et al. Among authors: pluckthun a. Clin Cancer Res. 2003 Jul;9(7):2837-48. Clin Cancer Res. 2003. PMID: 12855664

5

PEGylation and multimerization of the anti-p185HER-2 single chain Fv fragment 4D5: effects on tumor targeting.

Kubetzko S, Balic E, Waibel R, Zangemeister-Wittke U, Plückthun A. Kubetzko S, et al. Among authors: pluckthun a. J Biol Chem. 2006 Nov 17;281(46):35186-201. doi: 10.1074/jbc.M604127200. Epub 2006 Sep 8. J Biol Chem. 2006. PMID: 16963450 Free article.

6

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity.

Sarkar CA, Dodevski I, Kenig M, Dudli S, Mohr A, Hermans E, Plückthun A. Sarkar CA, et al. Among authors: pluckthun a. Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):14808-13. doi: 10.1073/pnas.0803103105. Epub 2008 Sep 23. Proc Natl Acad Sci U S A. 2008. PMID: 18812512 Free PMC article.

7

Selection and characterization of DARPins specific for the neurotensin receptor 1.

Milovnik P, Ferrari D, Sarkar CA, Plückthun A. Milovnik P, et al. Among authors: pluckthun a. Protein Eng Des Sel. 2009 Jun;22(6):357-66. doi: 10.1093/protein/gzp011. Epub 2009 Apr 22. Protein Eng Des Sel. 2009. PMID: 19389717 Free PMC article.

8

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution.

Zahnd C, Sarkar CA, Plückthun A. Zahnd C, et al. Among authors: pluckthun a. Protein Eng Des Sel. 2010 Apr;23(4):175-84. doi: 10.1093/protein/gzp087. Epub 2010 Feb 3. Protein Eng Des Sel. 2010. PMID: 20130104 Free article.

9

Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.

Simon M, Stefan N, Borsig L, Plückthun A, Zangemeister-Wittke U. Simon M, et al. Among authors: pluckthun a. Mol Cancer Ther. 2014 Feb;13(2):375-85. doi: 10.1158/1535-7163.MCT-13-0523. Epub 2013 Nov 1. Mol Cancer Ther. 2014. PMID: 24184633

10

Novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting.

Stefan N, Zimmermann M, Simon M, Zangemeister-Wittke U, Plückthun A. Stefan N, et al. Among authors: pluckthun a. Bioconjug Chem. 2014 Dec 17;25(12):2144-56. doi: 10.1021/bc500468s. Epub 2014 Nov 14. Bioconjug Chem. 2014. PMID: 25350699

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