Cosford ND - Search Results

1

Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.

Chua PC, Nagasawa JY, Bleicher LS, Munoz B, Schweiger EJ, Tehrani L, Anderson JJ, Cramer M, Chung J, Green MD, King CD, Reyes-Manalo G, Cosford ND. Chua PC, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4589-93. doi: 10.1016/j.bmcl.2005.06.099. Bioorg Med Chem Lett. 2005. PMID: 16115767

2

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Cosford ND, Tehrani L, Roppe J, Schweiger E, Smith ND, Anderson J, Bristow L, Brodkin J, Jiang X, McDonald I, Rao S, Washburn M, Varney MA. Cosford ND, et al. J Med Chem. 2003 Jan 16;46(2):204-6. doi: 10.1021/jm025570j. J Med Chem. 2003. PMID: 12519057

3

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.

Cosford ND, Roppe J, Tehrani L, Schweiger EJ, Seiders TJ, Chaudary A, Rao S, Varney MA. Cosford ND, et al. Bioorg Med Chem Lett. 2003 Feb 10;13(3):351-4. doi: 10.1016/s0960-894x(02)00997-6. Bioorg Med Chem Lett. 2003. PMID: 12565928

4

5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.

Roppe JR, Wang B, Huang D, Tehrani L, Kamenecka T, Schweiger EJ, Anderson JJ, Brodkin J, Jiang X, Cramer M, Chung J, Reyes-Manalo G, Munoz B, Cosford ND. Roppe JR, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3993-6. doi: 10.1016/j.bmcl.2004.05.037. Bioorg Med Chem Lett. 2004. PMID: 15225713

5

Discovery of novel heteroarylazoles that are metabotropic glutamate subtype 5 receptor antagonists with anxiolytic activity.

Roppe J, Smith ND, Huang D, Tehrani L, Wang B, Anderson J, Brodkin J, Chung J, Jiang X, King C, Munoz B, Varney MA, Prasit P, Cosford ND. Roppe J, et al. Among authors: cosford nd. J Med Chem. 2004 Sep 9;47(19):4645-8. doi: 10.1021/jm049828c. J Med Chem. 2004. PMID: 15341479

6

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.

Hu E, Chua PC, Tehrani L, Nagasawa JY, Pinkerton AB, Rowe BA, Vernier JM, Hutchinson JH, Cosford ND. Hu E, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5071-4. doi: 10.1016/j.bmcl.2004.07.079. Bioorg Med Chem Lett. 2004. PMID: 15380201

7

2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Huang D, Poon SF, Chapman DF, Chung J, Cramer M, Reger TS, Roppe JR, Tehrani L, Cosford ND, Smith ND. Huang D, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5473-6. doi: 10.1016/j.bmcl.2004.09.012. Bioorg Med Chem Lett. 2004. PMID: 15482906

8

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.

Poon SF, Eastman BW, Chapman DF, Chung J, Cramer M, Holtz G, Cosford ND, Smith ND. Poon SF, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5477-80. doi: 10.1016/j.bmcl.2004.09.011. Bioorg Med Chem Lett. 2004. PMID: 15482907

9

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.

Smith ND, Poon SF, Huang D, Green M, King C, Tehrani L, Roppe JR, Chung J, Chapman DP, Cramer M, Cosford ND. Smith ND, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5481-4. doi: 10.1016/j.bmcl.2004.09.018. Bioorg Med Chem Lett. 2004. PMID: 15482908

10

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology.

Eastman B, Chen C, Smith ND, Poon S, Chung J, Reyes-Manalo G, Cosford ND, Munoz B. Eastman B, et al. Among authors: cosford nd. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5485-8. doi: 10.1016/j.bmcl.2004.09.016. Bioorg Med Chem Lett. 2004. PMID: 15482909

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

103 results

Search Page

Filters