Nicklaus MC - Search Results

1

Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.

Kang JH, Peach ML, Pu Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE. Kang JH, et al. Among authors: nicklaus mc. J Med Chem. 2005 Sep 8;48(18):5738-48. doi: 10.1021/jm050352m. J Med Chem. 2005. PMID: 16134942 Free PMC article.

2

Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.

Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ Jr. Rodriguez JB, et al. Among authors: nicklaus mc. J Med Chem. 1994 Sep 30;37(20):3389-99. doi: 10.1021/jm00046a024. J Med Chem. 1994. PMID: 7932567

3

Protein kinase C. Modeling of the binding site and prediction of binding constants.

Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM. Wang S, et al. Among authors: nicklaus mc. J Med Chem. 1994 Apr 29;37(9):1326-38. doi: 10.1021/jm00035a013. J Med Chem. 1994. PMID: 8176711

4

Conformational changes of small molecules binding to proteins.

Nicklaus MC, Wang S, Driscoll JS, Milne GW. Nicklaus MC, et al. Bioorg Med Chem. 1995 Apr;3(4):411-28. doi: 10.1016/0968-0896(95)00031-b. Bioorg Med Chem. 1995. PMID: 8581425

5

Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.

Wang S, Milne GW, Yan X, Posey IJ, Nicklaus MC, Graham L, Rice WG. Wang S, et al. Among authors: nicklaus mc. J Med Chem. 1996 May 10;39(10):2047-54. doi: 10.1021/jm950874+. J Med Chem. 1996. PMID: 8642563

6

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

Mazumder A, Wang S, Neamati N, Nicklaus M, Sunder S, Chen J, Milne GW, Rice WG, Burke TR Jr, Pommier Y. Mazumder A, et al. J Med Chem. 1996 Jun 21;39(13):2472-81. doi: 10.1021/jm960074e. J Med Chem. 1996. PMID: 8691444

7

HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.

Nicklaus MC, Neamati N, Hong H, Mazumder A, Sunder S, Chen J, Milne GW, Pommier Y. Nicklaus MC, et al. J Med Chem. 1997 Mar 14;40(6):920-9. doi: 10.1021/jm960596u. J Med Chem. 1997. PMID: 9083480

8

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

Hong H, Neamati N, Wang S, Nicklaus MC, Mazumder A, Zhao H, Burke TR Jr, Pommier Y, Milne GW. Hong H, et al. Among authors: nicklaus mc. J Med Chem. 1997 Mar 14;40(6):930-6. doi: 10.1021/jm960754h. J Med Chem. 1997. PMID: 9083481

9

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

Neamati N, Hong H, Mazumder A, Wang S, Sunder S, Nicklaus MC, Milne GW, Proksa B, Pommier Y. Neamati N, et al. Among authors: nicklaus mc. J Med Chem. 1997 Mar 14;40(6):942-51. doi: 10.1021/jm960759e. J Med Chem. 1997. PMID: 9083483

10

Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.

Marquez VE, Russ P, Alonso R, Siddiqui MA, Shin KJ, George C, Nicklaus MC, Dai F, Ford H Jr. Marquez VE, et al. Among authors: nicklaus mc. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):521-30. doi: 10.1080/15257779908041487. Nucleosides Nucleotides. 1999. PMID: 10432643

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