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Page 1
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA. Brischwein K, et al. Mol Immunol. 2006 Mar;43(8):1129-43. doi: 10.1016/j.molimm.2005.07.034. Epub 2005 Sep 1. Mol Immunol. 2006. PMID: 16139892
Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.
Schlereth B, Fichtner I, Lorenczewski G, Kleindienst P, Brischwein K, da Silva A, Kufer P, Lutterbuese R, Junghahn I, Kasimir-Bauer S, Wimberger P, Kimmig R, Baeuerle PA. Schlereth B, et al. Among authors: brischwein k. Cancer Res. 2005 Apr 1;65(7):2882-9. doi: 10.1158/0008-5472.CAN-04-2637. Cancer Res. 2005. PMID: 15805290
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3.
Schlereth B, Kleindienst P, Fichtner I, Lorenczewski G, Brischwein K, Lippold S, da Silva A, Locher M, Kischel R, Lutterbüse R, Kufer P, Baeuerle PA. Schlereth B, et al. Among authors: brischwein k. Cancer Immunol Immunother. 2006 Jul;55(7):785-96. doi: 10.1007/s00262-005-0082-x. Epub 2005 Sep 27. Cancer Immunol Immunother. 2006. PMID: 16187083 Free PMC article.
Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model.
Lutterbuese P, Brischwein K, Hofmeister R, Crommer S, Lorenczewski G, Petersen L, Lippold S, da Silva A, Locher M, Baeuerle PA, Schlereth B. Lutterbuese P, et al. Among authors: brischwein k. Cancer Immunol Immunother. 2007 Apr;56(4):459-68. doi: 10.1007/s00262-006-0218-7. Epub 2006 Aug 26. Cancer Immunol Immunother. 2007. PMID: 16937114 Free PMC article.
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct.
Brandl C, Haas C, d'Argouges S, Fisch T, Kufer P, Brischwein K, Prang N, Bargou R, Suzich J, Baeuerle PA, Hofmeister R. Brandl C, et al. Among authors: brischwein k. Cancer Immunol Immunother. 2007 Oct;56(10):1551-63. doi: 10.1007/s00262-007-0298-z. Epub 2007 Feb 20. Cancer Immunol Immunother. 2007. PMID: 17310380 Free PMC article.
Mode of cytotoxic action of T cell-engaging BiTE antibody MT110.
Haas C, Krinner E, Brischwein K, Hoffmann P, Lutterbüse R, Schlereth B, Kufer P, Baeuerle PA. Haas C, et al. Among authors: brischwein k. Immunobiology. 2009;214(6):441-53. doi: 10.1016/j.imbio.2008.11.014. Epub 2009 Jan 20. Immunobiology. 2009. PMID: 19157637
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