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114 results

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MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA. Brischwein K, et al. Among authors: locher m. Mol Immunol. 2006 Mar;43(8):1129-43. doi: 10.1016/j.molimm.2005.07.034. Epub 2005 Sep 1. Mol Immunol. 2006. PMID: 16139892
Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3.
Schlereth B, Kleindienst P, Fichtner I, Lorenczewski G, Brischwein K, Lippold S, da Silva A, Locher M, Kischel R, Lutterbüse R, Kufer P, Baeuerle PA. Schlereth B, et al. Among authors: locher m. Cancer Immunol Immunother. 2006 Jul;55(7):785-96. doi: 10.1007/s00262-005-0082-x. Epub 2005 Sep 27. Cancer Immunol Immunother. 2006. PMID: 16187083 Free PMC article.
A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF.
Krinner EM, Raum T, Petsch S, Bruckmaier S, Schuster I, Petersen L, Cierpka R, Abebe D, Mølhøj M, Wolf A, Sørensen P, Locher M, Baeuerle PA, Hepp J. Krinner EM, et al. Among authors: locher m. Mol Immunol. 2007 Feb;44(5):916-25. doi: 10.1016/j.molimm.2006.03.020. Epub 2006 May 11. Mol Immunol. 2007. PMID: 16697465
Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model.
Lutterbuese P, Brischwein K, Hofmeister R, Crommer S, Lorenczewski G, Petersen L, Lippold S, da Silva A, Locher M, Baeuerle PA, Schlereth B. Lutterbuese P, et al. Among authors: locher m. Cancer Immunol Immunother. 2007 Apr;56(4):459-68. doi: 10.1007/s00262-006-0218-7. Epub 2006 Aug 26. Cancer Immunol Immunother. 2007. PMID: 16937114 Free PMC article.
Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells.
d'Argouges S, Wissing S, Brandl C, Prang N, Lutterbuese R, Kozhich A, Suzich J, Locher M, Kiener P, Kufer P, Hofmeister R, Baeuerle PA, Bargou RC. d'Argouges S, et al. Among authors: locher m. Leuk Res. 2009 Mar;33(3):465-73. doi: 10.1016/j.leukres.2008.08.025. Epub 2008 Oct 2. Leuk Res. 2009. PMID: 18835037
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases.
Silacci M, Lembke W, Woods R, Attinger-Toller I, Baenziger-Tobler N, Batey S, Santimaria R, von der Bey U, Koenig-Friedrich S, Zha W, Schlereth B, Locher M, Bertschinger J, Grabulovski D. Silacci M, et al. Among authors: locher m. MAbs. 2016;8(1):141-9. doi: 10.1080/19420862.2015.1093266. Epub 2015 Sep 22. MAbs. 2016. PMID: 26390837 Free PMC article. Clinical Trial.
New challenges and opportunities in nonclinical safety testing of biologics.
Baumann A, Flagella K, Forster R, de Haan L, Kronenberg S, Locher M, Richter WF, Theil FP, Todd M. Baumann A, et al. Among authors: locher m. Regul Toxicol Pharmacol. 2014 Jul;69(2):226-33. doi: 10.1016/j.yrtph.2014.04.005. Epub 2014 Apr 19. Regul Toxicol Pharmacol. 2014. PMID: 24755365
114 results