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A comparison of the cyclooxygenase inhibitor-NO donors (CINOD), NMI-1182 and AZD3582, using in vitro biochemical and pharmacological methods.
Young DV, Cochran ED, Dhawan V, Earl RA, Ellis JL, Garvey DS, Janero DR, Khanapure SP, Letts LG, Melim TL, Murty MG, Shumway MJ, Wey SJ, Zemtseva IS, Selig WM. Young DV, et al. Among authors: selig wm. Biochem Pharmacol. 2005 Nov 1;70(9):1343-51. doi: 10.1016/j.bcp.2005.08.004. Biochem Pharmacol. 2005. PMID: 16168964
NMI-1182, a gastro-protective cyclo-oxygenase-inhibiting nitric oxide donor.
Ellis JL, Augustyniak ME, Cochran ED, Earl RA, Garvey DS, Gordon LJ, Janero DR, Khanapure SP, Letts LG, Melim TL, Murty MG, Schwalb DJ, Shumway MJ, Selig WM, Trocha AM, Young DV, Zemtseva IS. Ellis JL, et al. Among authors: selig wm. Inflammopharmacology. 2005;12(5-6):521-34. doi: 10.1163/156856005774382661. Inflammopharmacology. 2005. PMID: 16259719
Structure-based design, synthesis, and biological evaluation of indomethacin derivatives as cyclooxygenase-2 inhibiting nitric oxide donors.
Wey SJ, Augustyniak ME, Cochran ED, Ellis JL, Fang X, Garvey DS, Janero DR, Letts LG, Martino AM, Melim TL, Murty MG, Richardson SK, Schroeder JD, Selig WM, Trocha AM, Wexler RS, Young DV, Zemtseva IS, Zifcak BM. Wey SJ, et al. Among authors: selig wm. J Med Chem. 2007 Dec 13;50(25):6367-82. doi: 10.1021/jm0611861. Epub 2007 Nov 10. J Med Chem. 2007. PMID: 17994684
Novel dual acting molecules possessing 5-lipoxygenase enzyme inhibition and histamine H(1) receptor antagonist properties.
Scannell RT, Arrington MP, Bayless L, Cai X, Eckman JB, Eckert M, Ene DG, Ellis JL, Hussoin S, Latham GM, Lewis TA, Libertine L, Nicolas J, Selig WM, Schwartz CE, Wels BF, Wypij DM, Young MA, Zou D. Scannell RT, et al. Among authors: selig wm. Inflamm Res. 2004 Mar;53 Suppl 1:S33-4. doi: 10.1007/s00011-003-0315-4. Epub 2004 Mar 5. Inflamm Res. 2004. PMID: 15054606 No abstract available.
Bradykinin antagonists in human systems: correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum.
Wieczorek M, Pilyavskaya A, Burkard M, Zuzack JS, Jones SW, Francis MD, Beckey VE, Ross SE, Goodfellow VS, Fitzpatrick TD, Marathe MV, Gyorkos A, Spruce LW, Selig WM, Stewart JM, Gera L, Whalley ET. Wieczorek M, et al. Among authors: selig wm. Biochem Pharmacol. 1997 Jul 15;54(2):283-91. doi: 10.1016/s0006-2952(97)00186-x. Biochem Pharmacol. 1997. PMID: 9271333
43 results