Dean FB - Search Results

1

Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase.

Ochsner UA, Young CL, Stone KC, Dean FB, Janjic N, Critchley IA. Ochsner UA, et al. Among authors: dean fb. Antimicrob Agents Chemother. 2005 Oct;49(10):4253-62. doi: 10.1128/AAC.49.10.4253-4262.2005. Antimicrob Agents Chemother. 2005. PMID: 16189106 Free PMC article.

2

Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity.

Green LS, Bullard JM, Ribble W, Dean F, Ayers DF, Ochsner UA, Janjic N, Jarvis TC. Green LS, et al. Antimicrob Agents Chemother. 2009 Jan;53(1):86-94. doi: 10.1128/AAC.00275-08. Epub 2008 Nov 17. Antimicrob Agents Chemother. 2009. PMID: 19015366 Free PMC article.

3

Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.

Guiles J, Sun X, Critchley IA, Ochsner U, Tregay M, Stone K, Bertino J, Green L, Sabin R, Dean F, Dallmann HG, McHenry CS, Janjic N. Guiles J, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):800-2. doi: 10.1016/j.bmcl.2008.12.038. Epub 2008 Dec 13. Bioorg Med Chem Lett. 2009. PMID: 19109016

4

Identification and Characterization of a Chemical Compound that Inhibits Methionyl-tRNA Synthetase from Pseudomonas aeruginosa.

Robles S, Hu Y, Resto T, Dean F, Bullard JM. Robles S, et al. Curr Drug Discov Technol. 2017;14(3):156-168. doi: 10.2174/1570163814666170330100238. Curr Drug Discov Technol. 2017. PMID: 28359232 Free PMC article.

5

Glutaminyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization, structure, and development as a screening platform.

Escamilla Y, Hughes CA, Abendroth J, Dranow DM, Balboa S, Dean FB, Bullard JM. Escamilla Y, et al. Among authors: dean fb. Protein Sci. 2020 Apr;29(4):905-918. doi: 10.1002/pro.3800. Epub 2019 Dec 24. Protein Sci. 2020. PMID: 31833153 Free PMC article.

6

Discovery and Characterization of Chemical Compounds That Inhibit the Function of Aspartyl-tRNA Synthetase from Pseudomonas aeruginosa.

Corona A, Palmer SO, Zamacona R, Mendez B, Dean FB, Bullard JM. Corona A, et al. Among authors: dean fb. SLAS Discov. 2018 Mar;23(3):294-301. doi: 10.1177/2472555217744559. Epub 2017 Nov 29. SLAS Discov. 2018. PMID: 29186665 Free PMC article.

7

Identification of Chemical Compounds That Inhibit the Function of Histidyl-tRNA Synthetase from Pseudomonas aeruginosa.

Hu Y, Palmer SO, Robles ST, Resto T, Dean FB, Bullard JM. Hu Y, et al. Among authors: dean fb. SLAS Discov. 2018 Jan;23(1):65-75. doi: 10.1177/2472555217722016. Epub 2017 Jul 26. SLAS Discov. 2018. PMID: 28745975 Free PMC article.

8

Lysyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization and Identification of Inhibitory Compounds.

Balboa S, Hu Y, Dean FB, Bullard JM. Balboa S, et al. Among authors: dean fb. SLAS Discov. 2020 Jan;25(1):57-69. doi: 10.1177/2472555219873095. Epub 2019 Sep 9. SLAS Discov. 2020. PMID: 31498734 Free PMC article.

9

Two Forms of Tyrosyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization and Discovery of Inhibitory Compounds.

Hughes CA, Gorabi V, Escamilla Y, Dean FB, Bullard JM. Hughes CA, et al. Among authors: dean fb. SLAS Discov. 2020 Oct;25(9):1072-1086. doi: 10.1177/2472555220934793. Epub 2020 Jun 25. SLAS Discov. 2020. PMID: 32583746 Free PMC article.

10

Rational Design of an Antimicrobial Peptide Based on Structural Insight into the Interaction of Pseudomonas aeruginosa Initiation Factor 1 with Its Cognate 30S Ribosomal Subunit.

Valdez N, Hughes C, Palmer SO, Sepulveda A, Dean FB, Escamilla Y, Bullard JM, Zhang Y. Valdez N, et al. Among authors: dean fb. ACS Infect Dis. 2021 Dec 10;7(12):3161-3167. doi: 10.1021/acsinfecdis.1c00256. Epub 2021 Oct 28. ACS Infect Dis. 2021. PMID: 34709785

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