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Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism.
Kawata T, Imanishi Y, Kobayashi K, Kenko T, Wada M, Ishimura E, Miki T, Nagano N, Inaba M, Arnold A, Nishizawa Y. Kawata T, et al. Among authors: wada m. Eur J Endocrinol. 2005 Oct;153(4):587-94. doi: 10.1530/eje.1.02007. Eur J Endocrinol. 2005. PMID: 16189180
Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels.
Kawata T, Imanishi Y, Kobayashi K, Onoda N, Okuno S, Takemoto Y, Komo T, Tahara H, Wada M, Nagano N, Ishimura E, Miki T, Ishikawa T, Inaba M, Nishizawa Y. Kawata T, et al. Among authors: wada m. J Bone Miner Metab. 2006;24(4):300-6. doi: 10.1007/s00774-006-0687-y. J Bone Miner Metab. 2006. PMID: 16816924
A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro.
Kawata T, Tokunaga S, Murai M, Masuda N, Haruyama W, Shoukei Y, Hisada Y, Yanagida T, Miyazaki H, Wada M, Akizawa T, Fukagawa M. Kawata T, et al. Among authors: wada m. PLoS One. 2018 Apr 3;13(4):e0195316. doi: 10.1371/journal.pone.0195316. eCollection 2018. PLoS One. 2018. PMID: 29614098 Free PMC article.
2,874 results