Metzger A - Search Results

1

5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.

Liu C, Wrobleski ST, Lin J, Ahmed G, Metzger A, Wityak J, Gillooly KM, Shuster DJ, McIntyre KW, Pitt S, Shen DR, Zhang RF, Zhang H, Doweyko AM, Diller D, Henderson I, Barrish JC, Dodd JH, Schieven GL, Leftheris K. Liu C, et al. Among authors: metzger a. J Med Chem. 2005 Oct 6;48(20):6261-70. doi: 10.1021/jm0503594. J Med Chem. 2005. PMID: 16190753

2

The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.

Leftheris K, Ahmed G, Chan R, Dyckman AJ, Hussain Z, Ho K, Hynes J Jr, Letourneau J, Li W, Lin S, Metzger A, Moriarty KJ, Riviello C, Shimshock Y, Wen J, Wityak J, Wrobleski ST, Wu H, Wu J, Desai M, Gillooly KM, Lin TH, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Zhang R, Diller D, Doweyko A, Sack J, Baldwin J, Barrish J, Dodd J, Henderson I, Kanner S, Schieven GL, Webb M. Leftheris K, et al. Among authors: metzger a. J Med Chem. 2004 Dec 2;47(25):6283-91. doi: 10.1021/jm049521d. J Med Chem. 2004. PMID: 15566298

3

The discovery of novel chemotypes of p38 kinase inhibitors.

Diller DJ, Lin TH, Metzger A. Diller DJ, et al. Among authors: metzger a. Curr Top Med Chem. 2005;5(10):953-65. doi: 10.2174/1568026054985948. Curr Top Med Chem. 2005. PMID: 16178740 Review.

4

Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.

Lin TH, Metzger A, Diller DJ, Desai M, Henderson I, Ahmed G, Kimble EF, Quadros E, Webb ML. Lin TH, et al. Among authors: metzger a. J Pharmacol Exp Ther. 2006 Aug;318(2):495-502. doi: 10.1124/jpet.105.097568. Epub 2006 May 15. J Pharmacol Exp Ther. 2006. PMID: 16702443

5

Successful screening of large encoded combinatorial libraries leading to the discovery of novel p38 MAP kinase inhibitors.

Metzger A, Diller DJ, Lin TH, Henderson I, Webb ML. Metzger A, et al. Comb Chem High Throughput Screen. 2006 Jun;9(5):351-8. doi: 10.2174/138620706777452384. Comb Chem High Throughput Screen. 2006. PMID: 16787148

6

Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists.

Cole AG, Stauffer TM, Rokosz LL, Metzger A, Dillard LW, Zeng W, Henderson I. Cole AG, et al. Among authors: metzger a. Bioorg Med Chem Lett. 2009 Jan 15;19(2):378-81. doi: 10.1016/j.bmcl.2008.11.066. Epub 2008 Nov 24. Bioorg Med Chem Lett. 2009. PMID: 19059776

7

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists.

Cole AG, Metzger A, Brescia MR, Qin LY, Appell KC, Brain CT, Hallett A, Ganju P, Denholm AA, Wareing JR, Ritchie TJ, Drake GM, Bevan SJ, MacGloinn A, McBryde A, Patel V, Oakley PJ, Nunez X, Gstach H, Schneider P, Baldwin JJ, Dolle RE, McDonald E, Henderson I. Cole AG, et al. Among authors: metzger a. Bioorg Med Chem Lett. 2009 Jan 1;19(1):119-22. doi: 10.1016/j.bmcl.2008.11.005. Epub 2008 Nov 6. Bioorg Med Chem Lett. 2009. PMID: 19014884

8

Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.

Ludwig ML, Pattridge KA, Metzger AL, Dixon MM, Eren M, Feng Y, Swenson RP. Ludwig ML, et al. Among authors: metzger al. Biochemistry. 1997 Feb 11;36(6):1259-80. doi: 10.1021/bi962180o. Biochemistry. 1997. PMID: 9063874

9

Structure and oxidation-reduction behavior of 1-deaza-FMN flavodoxins: modulation of redox potentials in flavodoxins.

Ludwig ML, Schopfer LM, Metzger AL, Pattridge KA, Massey V. Ludwig ML, et al. Among authors: metzger al. Biochemistry. 1990 Nov 13;29(45):10364-75. doi: 10.1021/bi00497a011. Biochemistry. 1990. PMID: 2261478

10

Manganese superoxide dismutase from Thermus thermophilus. A structural model refined at 1.8 A resolution.

Ludwig ML, Metzger AL, Pattridge KA, Stallings WC. Ludwig ML, et al. Among authors: metzger al. J Mol Biol. 1991 May 20;219(2):335-58. doi: 10.1016/0022-2836(91)90569-r. J Mol Biol. 1991. PMID: 2038060 Free article.

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