Klock HE - Search Results

1

Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors.

Han S, Zhou V, Pan S, Liu Y, Hornsby M, McMullan D, Klock HE, Haugen J, Lesley SA, Gray N, Caldwell J, Gu XJ. Han S, et al. Among authors: klock he. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73. doi: 10.1016/j.bmcl.2005.08.097. Epub 2005 Sep 30. Bioorg Med Chem Lett. 2005. PMID: 16199156

2

A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors.

Zhou V, Han S, Brinker A, Klock H, Caldwell J, Gu XJ. Zhou V, et al. Anal Biochem. 2004 Aug 15;331(2):349-57. doi: 10.1016/j.ab.2004.04.011. Anal Biochem. 2004. PMID: 15265741

3

Advances in high-throughput methodologies for crystallizing proteins.

Chamberlain PP, Klock HE, McMullan D, DiDonato M, Kreusch A, Lesley SA, Spraggon G. Chamberlain PP, et al. Among authors: klock he. Biotechnol Genet Eng Rev. 2006;23:1-19. doi: 10.1080/02648725.2006.10648075. Biotechnol Genet Eng Rev. 2006. PMID: 22530499 Review. No abstract available.

4

A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome.

DiDonato M, Deacon AM, Klock HE, McMullan D, Lesley SA. DiDonato M, et al. Among authors: klock he. J Struct Funct Genomics. 2004;5(1-2):133-46. doi: 10.1023/B:JSFG.0000029194.04443.50. J Struct Funct Genomics. 2004. PMID: 15263852

5

Methods and results for semi-automated cloning using integrated robotics.

Klock HE, White A, Koesema E, Lesley SA. Klock HE, et al. J Struct Funct Genomics. 2005;6(2-3):89-94. doi: 10.1007/s10969-005-3084-1. J Struct Funct Genomics. 2005. PMID: 16211504

6

High-throughput protein production for X-ray crystallography and use of size exclusion chromatography to validate or refute computational biological unit predictions.

McMullan D, Canaves JM, Quijano K, Abdubek P, Nigoghossian E, Haugen J, Klock HE, Vincent J, Hale J, Paulsen J, Lesley SA. McMullan D, et al. Among authors: klock he. J Struct Funct Genomics. 2005;6(2-3):135-41. doi: 10.1007/s10969-005-2898-1. J Struct Funct Genomics. 2005. PMID: 16211510

7

The Polymerase Incomplete Primer Extension (PIPE) method applied to high-throughput cloning and site-directed mutagenesis.

Klock HE, Lesley SA. Klock HE, et al. Methods Mol Biol. 2009;498:91-103. doi: 10.1007/978-1-59745-196-3_6. Methods Mol Biol. 2009. PMID: 18988020

8

Structure analysis of peptide deformylases from Streptococcus pneumoniae, Staphylococcus aureus, Thermotoga maritima and Pseudomonas aeruginosa: snapshots of the oxygen sensitivity of peptide deformylase.

Kreusch A, Spraggon G, Lee CC, Klock H, McMullan D, Ng K, Shin T, Vincent J, Warner I, Ericson C, Lesley SA. Kreusch A, et al. J Mol Biol. 2003 Jul 4;330(2):309-21. doi: 10.1016/s0022-2836(03)00596-5. J Mol Biol. 2003. PMID: 12823970

9

Gene expression response to misfolded protein as a screen for soluble recombinant protein.

Lesley SA, Graziano J, Cho CY, Knuth MW, Klock HE. Lesley SA, et al. Among authors: klock he. Protein Eng. 2002 Feb;15(2):153-60. doi: 10.1093/protein/15.2.153. Protein Eng. 2002. PMID: 11917152

10

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171.

Spraggon G, Pantazatos D, Klock HE, Wilson IA, Woods VL Jr, Lesley SA. Spraggon G, et al. Among authors: klock he. Protein Sci. 2004 Dec;13(12):3187-99. doi: 10.1110/ps.04939904. Protein Sci. 2004. PMID: 15557262 Free PMC article.

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