Leys D - Search Results

1

The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase.

Neeli R, Girvan HM, Lawrence A, Warren MJ, Leys D, Scrutton NS, Munro AW. Neeli R, et al. Among authors: leys d. FEBS Lett. 2005 Oct 24;579(25):5582-8. doi: 10.1016/j.febslet.2005.09.023. Epub 2005 Sep 28. FEBS Lett. 2005. PMID: 16214136 Free article.

2

Crystallization and preliminary crystallographic analysis of a novel cytochrome P450 from Mycobacterium tuberculosis.

Mowat CG, Leys D, McLean KJ, Rivers SL, Richmond A, Munro AW, Ortiz Lombardia M, Alzari PM, Reid GA, Chapman SK, Walkinshaw MD. Mowat CG, et al. Among authors: leys d. Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):704-5. doi: 10.1107/s0907444902002676. Epub 2002 Mar 22. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11914502 Free article.

3

P450 BM3: the very model of a modern flavocytochrome.

Munro AW, Leys DG, McLean KJ, Marshall KR, Ost TW, Daff S, Miles CS, Chapman SK, Lysek DA, Moser CC, Page CC, Dutton PL. Munro AW, et al. Trends Biochem Sci. 2002 May;27(5):250-7. doi: 10.1016/s0968-0004(02)02086-8. Trends Biochem Sci. 2002. PMID: 12076537 Review.

4

Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.

McLean KJ, Cheesman MR, Rivers SL, Richmond A, Leys D, Chapman SK, Reid GA, Price NC, Kelly SM, Clarkson J, Smith WE, Munro AW. McLean KJ, et al. Among authors: leys d. J Inorg Biochem. 2002 Sep 20;91(4):527-41. doi: 10.1016/s0162-0134(02)00479-8. J Inorg Biochem. 2002. PMID: 12237220

5

Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450.

Leys D, Mowat CG, McLean KJ, Richmond A, Chapman SK, Walkinshaw MD, Munro AW. Leys D, et al. J Biol Chem. 2003 Feb 14;278(7):5141-7. doi: 10.1074/jbc.M209928200. Epub 2002 Nov 14. J Biol Chem. 2003. PMID: 12435731 Free article.

6

Extensive conformational sampling in a ternary electron transfer complex.

Leys D, Basran J, Talfournier F, Sutcliffe MJ, Scrutton NS. Leys D, et al. Nat Struct Biol. 2003 Mar;10(3):219-25. doi: 10.1038/nsb894. Nat Struct Biol. 2003. PMID: 12567183

7

Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.

Munro AW, McLean KJ, Marshall KR, Warman AJ, Lewis G, Roitel O, Sutcliffe MJ, Kemp CA, Modi S, Scrutton NS, Leys D. Munro AW, et al. Among authors: leys d. Biochem Soc Trans. 2003 Jun;31(Pt 3):625-30. doi: 10.1042/bst0310625. Biochem Soc Trans. 2003. PMID: 12773169 Review.

8

Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.

Leys D, Basran J, Scrutton NS. Leys D, et al. EMBO J. 2003 Aug 15;22(16):4038-48. doi: 10.1093/emboj/cdg395. EMBO J. 2003. PMID: 12912903 Free PMC article.

9

A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.

Joyce MG, Girvan HM, Munro AW, Leys D. Joyce MG, et al. Among authors: leys d. J Biol Chem. 2004 May 28;279(22):23287-93. doi: 10.1074/jbc.M401717200. Epub 2004 Mar 12. J Biol Chem. 2004. PMID: 15020590 Free article.

10

Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set.

Girvan HM, Marshall KR, Lawson RJ, Leys D, Joyce MG, Clarkson J, Smith WE, Cheesman MR, Munro AW. Girvan HM, et al. Among authors: leys d. J Biol Chem. 2004 May 28;279(22):23274-86. doi: 10.1074/jbc.M401716200. Epub 2004 Mar 12. J Biol Chem. 2004. PMID: 15020591 Free article.

Glutamate coordination of the heme iron is confirmed by structural studies of the A264E mutant (Joyce, M. G., Girvan, H. M., Munro, A. W., and Leys, D. (2004) J. Biol. Chem. 279, 23287-23293)....

Glutamate coordination of the heme iron is confirmed by structural studies of the A264E mutant (Joyce, M. G., Girvan, H. M., Munro, A. W., a …

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