Blundell TL - Search Results

1

Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes.

Robinson CJ, Harmer NJ, Goodger SJ, Blundell TL, Gallagher JT. Robinson CJ, et al. Among authors: blundell tl. J Biol Chem. 2005 Dec 23;280(51):42274-82. doi: 10.1074/jbc.M505720200. Epub 2005 Oct 11. J Biol Chem. 2005. PMID: 16219767 Free article.

2

Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex.

Harmer NJ, Ilag LL, Mulloy B, Pellegrini L, Robinson CV, Blundell TL. Harmer NJ, et al. Among authors: blundell tl. J Mol Biol. 2004 Jun 11;339(4):821-34. doi: 10.1016/j.jmb.2004.04.031. J Mol Biol. 2004. PMID: 15165853

3

Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.

Harmer NJ, Robinson CJ, Adam LE, Ilag LL, Robinson CV, Gallagher JT, Blundell TL. Harmer NJ, et al. Among authors: blundell tl. Biochem J. 2006 Feb 1;393(Pt 3):741-8. doi: 10.1042/BJ20050985. Biochem J. 2006. PMID: 16223363 Free PMC article.

4

Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms.

Goodger SJ, Robinson CJ, Murphy KJ, Gasiunas N, Harmer NJ, Blundell TL, Pye DA, Gallagher JT. Goodger SJ, et al. Among authors: blundell tl. J Biol Chem. 2008 May 9;283(19):13001-8. doi: 10.1074/jbc.M704531200. Epub 2008 Feb 14. J Biol Chem. 2008. PMID: 18281281 Free article.

5

Cooperative heparin-mediated oligomerization of fibroblast growth factor-1 (FGF1) precedes recruitment of FGFR2 to ternary complexes.

Brown A, Robinson CJ, Gallagher JT, Blundell TL. Brown A, et al. Among authors: blundell tl. Biophys J. 2013 Apr 16;104(8):1720-30. doi: 10.1016/j.bpj.2013.02.051. Biophys J. 2013. PMID: 23601319 Free PMC article.

6

The structural biology of growth factor receptor activation.

Harmer NJ, Chirgadze D, Hyun Kim K, Pellegrini L, Blundell TL. Harmer NJ, et al. Among authors: blundell tl. Biophys Chem. 2003;100(1-3):545-53. doi: 10.1016/s0301-4622(02)00305-8. Biophys Chem. 2003. PMID: 12646390

7

Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli.

Ryu EK, Cho KJ, Kim JK, Harmer NJ, Blundell TL, Kim KH. Ryu EK, et al. Among authors: blundell tl. Protein Expr Purif. 2006 Sep;49(1):15-22. doi: 10.1016/j.pep.2006.04.008. Epub 2006 Apr 27. Protein Expr Purif. 2006. PMID: 16750394

8

The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.

Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL. Harmer NJ, et al. Among authors: blundell tl. Biochemistry. 2004 Jan 27;43(3):629-40. doi: 10.1021/bi035320k. Biochemistry. 2004. PMID: 14730967

9

Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution.

Nagendra HG, Harrington AE, Harmer NJ, Pellegrini L, Blundell TL, Burke DF. Nagendra HG, et al. Among authors: blundell tl. FEBS Lett. 2001 Jul 13;501(1):51-8. doi: 10.1016/s0014-5793(01)02603-5. FEBS Lett. 2001. PMID: 11457455 Free article.

10

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL. Blaszczyk M, et al. Among authors: blundell tl. Prog Biophys Mol Biol. 2015 Sep;118(3):103-11. doi: 10.1016/j.pbiomolbio.2015.04.007. Epub 2015 May 5. Prog Biophys Mol Biol. 2015. PMID: 25957048 Free PMC article. Review.

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