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Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis.
Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Léoni AL, Steenman M, van Rijen HV, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JM, Grace AA, Escande D, Charpentier F. Royer A, et al. Among authors: leoni al. Circulation. 2005 Apr 12;111(14):1738-46. doi: 10.1161/01.CIR.0000160853.19867.61. Epub 2005 Apr 4. Circulation. 2005. PMID: 15809371
Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model.
Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F. Leoni AL, et al. PLoS One. 2010 Feb 19;5(2):e9298. doi: 10.1371/journal.pone.0009298. PLoS One. 2010. PMID: 20174578 Free PMC article.
The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.
Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. Mesirca P, et al. Among authors: leoni al. J Gen Physiol. 2013 Aug;142(2):113-26. doi: 10.1085/jgp.201310996. Epub 2013 Jul 15. J Gen Physiol. 2013. PMID: 23858001 Free PMC article.
G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.
Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME. Mesirca P, et al. Among authors: leoni al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831068 Free PMC article.
Rodent estrous cycle pattern: Harmonizing the cycle evaluation and interpretation.
Holalagoudar S, Kisielewski S, Martini A, Johnson K, Leoni AL, Demminger C, Brosel S. Holalagoudar S, et al. Among authors: leoni al. Regul Toxicol Pharmacol. 2024 Dec 21;156:105768. doi: 10.1016/j.yrtph.2024.105768. Online ahead of print. Regul Toxicol Pharmacol. 2024. PMID: 39716560 Review.
15 results