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Page 1
Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
Aicher TD, Anderson RC, Gao J, Shetty SS, Coppola GM, Stanton JL, Knorr DC, Sperbeck DM, Brand LJ, Vinluan CC, Kaplan EL, Dragland CJ, Tomaselli HC, Islam A, Lozito RJ, Liu X, Maniara WM, Fillers WS, DelGrande D, Walter RE, Mann WR. Aicher TD, et al. Among authors: knorr dc. J Med Chem. 2000 Jan 27;43(2):236-49. doi: 10.1021/jm990358+. J Med Chem. 2000. PMID: 10649979
Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
Bebernitz GR, Aicher TD, Stanton JL, Gao J, Shetty SS, Knorr DC, Strohschein RJ, Tan J, Brand LJ, Liu C, Wang WH, Vinluan CC, Kaplan EL, Dragland CJ, DelGrande D, Islam A, Lozito RJ, Liu X, Maniara WM, Mann WR. Bebernitz GR, et al. Among authors: knorr dc. J Med Chem. 2000 Jun 1;43(11):2248-57. doi: 10.1021/jm0000923. J Med Chem. 2000. PMID: 10841803
Hypoglycemic prodrugs of 4-(2,2-dimethyl-1-oxopropyl)benzoic acid.
Aicher TD, Bebernitz GR, Bell PA, Brand LJ, Dain JG, Deems R, Fillers WS, Foley JE, Knorr DC, Nadelson J, Otero DA, Simpson R, Strohschein RJ, Young DA. Aicher TD, et al. Among authors: knorr dc. J Med Chem. 1999 Jan 14;42(1):153-63. doi: 10.1021/jm980438y. J Med Chem. 1999. PMID: 9888840
(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase.
Aicher TD, Anderson RC, Bebernitz GR, Coppola GM, Jewell CF, Knorr DC, Liu C, Sperbeck DM, Brand LJ, Strohschein RJ, Gao J, Vinluan CC, Shetty SS, Dragland C, Kaplan EL, DelGrande D, Islam A, Liu X, Lozito RJ, Maniara WM, Walter RE, Mann WR. Aicher TD, et al. Among authors: knorr dc. J Med Chem. 1999 Jul 29;42(15):2741-6. doi: 10.1021/jm9902584. J Med Chem. 1999. PMID: 10425084 No abstract available.