Strub A - Search Results

1

The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.

Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R. Strub A, et al. Mol Pharmacol. 2006 Jan;69(1):328-37. doi: 10.1124/mol.105.017087. Epub 2005 Oct 13. Mol Pharmacol. 2006. PMID: 16223957

2

In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase.

Lehner MD, Marx D, Boer R, Strub A, Hesslinger C, Eltze M, Ulrich WR, Schwoebel F, Schermuly RT, Barsig J. Lehner MD, et al. Among authors: strub a. J Pharmacol Exp Ther. 2006 Apr;317(1):181-7. doi: 10.1124/jpet.105.098673. Epub 2005 Dec 20. J Pharmacol Exp Ther. 2006. PMID: 16368897

3

BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase.

Tiso M, Strub A, Hesslinger C, Kenney CT, Boer R, Stuehr DJ. Tiso M, et al. Among authors: strub a. Mol Pharmacol. 2008 Apr;73(4):1244-53. doi: 10.1124/mol.107.041319. Epub 2008 Jan 4. Mol Pharmacol. 2008. PMID: 18178668

4

Inhibition of inducible nitric oxide synthase in respiratory diseases.

Hesslinger C, Strub A, Boer R, Ulrich WR, Lehner MD, Braun C. Hesslinger C, et al. Among authors: strub a. Biochem Soc Trans. 2009 Aug;37(Pt 4):886-91. doi: 10.1042/BST0370886. Biochem Soc Trans. 2009. PMID: 19614613 Review.

5

Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights.

Grädler U, Fuchss T, Ulrich WR, Boer R, Strub A, Hesslinger C, Anézo C, Diederichs K, Zaliani A. Grädler U, et al. Among authors: strub a. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4228-32. doi: 10.1016/j.bmcl.2011.05.073. Epub 2011 May 30. Bioorg Med Chem Lett. 2011. PMID: 21684157

6

Montelukast exerts no acute direct effect on NO synthases.

Hamacher J, Eichert K, Braun C, Grebe T, Strub A, Lucas R, Eltze M, Wendel A. Hamacher J, et al. Among authors: strub a. Pulm Pharmacol Ther. 2007;20(5):525-33. doi: 10.1016/j.pupt.2006.05.001. Epub 2006 May 19. Pulm Pharmacol Ther. 2007. PMID: 16815057

7

The putative helical lid of the Hsp70 peptide-binding domain is required for efficient preprotein translocation into mitochondria.

Strub A, Zufall N, Voos W. Strub A, et al. J Mol Biol. 2003 Dec 12;334(5):1087-99. doi: 10.1016/j.jmb.2003.10.023. J Mol Biol. 2003. PMID: 14643668

8

The two mitochondrial heat shock proteins 70, Ssc1 and Ssq1, compete for the cochaperone Mge1.

Schmidt S, Strub A, Röttgers K, Zufall N, Voos W. Schmidt S, et al. Among authors: strub a. J Mol Biol. 2001 Oct 12;313(1):13-26. doi: 10.1006/jmbi.2001.5013. J Mol Biol. 2001. PMID: 11601843

9

The Hsp70 peptide-binding domain determines the interaction of the ATPase domain with Tim44 in mitochondria.

Strub A, Röttgers K, Voos W. Strub A, et al. EMBO J. 2002 Jun 3;21(11):2626-35. doi: 10.1093/emboj/21.11.2626. EMBO J. 2002. PMID: 12032075 Free PMC article.

10

Impaired interdomain communication in mitochondrial Hsp70 results in the loss of inward-directed translocation force.

Becker D, Krayl M, Strub A, Li Y, Mayer MP, Voos W. Becker D, et al. Among authors: strub a. J Biol Chem. 2009 Jan 30;284(5):2934-2946. doi: 10.1074/jbc.M803557200. Epub 2008 Nov 26. J Biol Chem. 2009. PMID: 19036727 Free article.

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