Benz RD - Search Results

1

In silico screening of chemicals for bacterial mutagenicity using electrotopological E-state indices and MDL QSAR software.

Contrera JF, Matthews EJ, Kruhlak NL, Benz RD. Contrera JF, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2005 Dec;43(3):313-23. doi: 10.1016/j.yrtph.2005.09.001. Epub 2005 Oct 19. Regul Toxicol Pharmacol. 2005. PMID: 16242226

2

Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose.

Contrera JF, Matthews EJ, Kruhlak NL, Benz RD. Contrera JF, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2004 Dec;40(3):185-206. doi: 10.1016/j.yrtph.2004.08.004. Regul Toxicol Pharmacol. 2004. PMID: 15546675

3

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods.

Matthews EJ, Kruhlak NL, Cimino MC, Benz RD, Contrera JF. Matthews EJ, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2006 Mar;44(2):97-110. doi: 10.1016/j.yrtph.2005.10.004. Epub 2005 Dec 13. Regul Toxicol Pharmacol. 2006. PMID: 16352383

4

An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints.

Matthews EJ, Kruhlak NL, Cimino MC, Benz RD, Contrera JF. Matthews EJ, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2006 Mar;44(2):83-96. doi: 10.1016/j.yrtph.2005.11.003. Epub 2005 Dec 28. Regul Toxicol Pharmacol. 2006. PMID: 16386343

5

Assessment of the health effects of chemicals in humans: I. QSAR estimation of the maximum recommended therapeutic dose (MRTD) and no effect level (NOEL) of organic chemicals based on clinical trial data.

Matthews EJ, Kruhlak NL, Benz RD, Contrera JF. Matthews EJ, et al. Among authors: benz rd. Curr Drug Discov Technol. 2004 Jan;1(1):61-76. doi: 10.2174/1570163043484789. Curr Drug Discov Technol. 2004. PMID: 16472220

6

Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.

Matthews EJ, Kruhlak NL, Weaver JL, Benz RD, Contrera JF. Matthews EJ, et al. Among authors: benz rd. Curr Drug Discov Technol. 2004 Dec;1(4):243-54. doi: 10.2174/1570163043334794. Curr Drug Discov Technol. 2004. PMID: 16472241

7

Progress in QSAR toxicity screening of pharmaceutical impurities and other FDA regulated products.

Kruhlak NL, Contrera JF, Benz RD, Matthews EJ. Kruhlak NL, et al. Among authors: benz rd. Adv Drug Deliv Rev. 2007 Jan 10;59(1):43-55. doi: 10.1016/j.addr.2006.10.008. Epub 2006 Nov 15. Adv Drug Deliv Rev. 2007. PMID: 17229485 Review.

8

Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models.

Contrera JF, Kruhlak NL, Matthews EJ, Benz RD. Contrera JF, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2007 Dec;49(3):172-82. doi: 10.1016/j.yrtph.2007.07.001. Epub 2007 Jul 17. Regul Toxicol Pharmacol. 2007. PMID: 17703860

9

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans. Part A: use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities.

Ursem CJ, Kruhlak NL, Contrera JF, MacLaughlin PM, Benz RD, Matthews EJ. Ursem CJ, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2009 Jun;54(1):1-22. doi: 10.1016/j.yrtph.2008.12.009. Regul Toxicol Pharmacol. 2009. PMID: 19422096

10

Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities.

Matthews EJ, Ursem CJ, Kruhlak NL, Benz RD, Sabaté DA, Yang C, Klopman G, Contrera JF. Matthews EJ, et al. Among authors: benz rd. Regul Toxicol Pharmacol. 2009 Jun;54(1):23-42. doi: 10.1016/j.yrtph.2009.01.009. Regul Toxicol Pharmacol. 2009. PMID: 19422098

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