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Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y, Kurihara H, Asano T. Kushiyama A, et al. J Biol Chem. 2005 Dec 23;280(51):42016-25. doi: 10.1074/jbc.M503065200. Epub 2005 Oct 21. J Biol Chem. 2005. PMID: 16243841 Free article.
Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Ogihara T, Asano T, Katagiri H, Sakoda H, Anai M, Shojima N, Ono H, Fujishiro M, Kushiyama A, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Gotoh Y, Komuro I, Fujita T. Ogihara T, et al. Among authors: kushiyama a. Diabetologia. 2004 May;47(5):794-805. doi: 10.1007/s00125-004-1391-x. Epub 2004 May 1. Diabetologia. 2004. PMID: 15127200
Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa.
Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M. Fukushima Y, et al. Among authors: kushiyama a. Eur J Pharmacol. 2004 Oct 19;502(3):243-52. doi: 10.1016/j.ejphar.2004.09.013. Eur J Pharmacol. 2004. PMID: 15476751
Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.
Shojima N, Ogihara T, Inukai K, Fujishiro M, Sakoda H, Kushiyama A, Katagiri H, Anai M, Ono H, Fukushima Y, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T. Shojima N, et al. Among authors: kushiyama a. Diabetologia. 2005 May;48(5):984-92. doi: 10.1007/s00125-005-1735-1. Epub 2005 Apr 15. Diabetologia. 2005. PMID: 15834545
Glycogen debranching enzyme association with beta-subunit regulates AMP-activated protein kinase activity.
Sakoda H, Fujishiro M, Fujio J, Shojima N, Ogihara T, Kushiyama A, Fukushima Y, Anai M, Ono H, Kikuchi M, Horike N, Viana AY, Uchijima Y, Kurihara H, Asano T. Sakoda H, et al. Among authors: kushiyama a. Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E474-81. doi: 10.1152/ajpendo.00003.2005. Epub 2005 May 10. Am J Physiol Endocrinol Metab. 2005. PMID: 15886229 Free article.
122 results