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Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety.
Richardson TI, Frank SA, Wang M, Clarke CA, Jones SA, Ying BP, Kohlman DT, Wallace OB, Shepherd TA, Dally RD, Palkowitz AD, Geiser AG, Bryant HU, Henck JW, Cohen IR, Rudmann DG, McCann DJ, Coutant DE, Oldham SW, Hummel CW, Fong KC, Hinklin R, Lewis G, Tian H, Dodge JA. Richardson TI, et al. Among authors: coutant de. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3544-9. doi: 10.1016/j.bmcl.2007.04.044. Epub 2007 Apr 24. Bioorg Med Chem Lett. 2007. PMID: 17482463
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron.
Sloop KW, Cox AL, Wainscott DB, White A, Droz BA, Stutsman C, Showalter AD, Suter TM, Dunbar JD, Snider BM, O'Farrell LS, Hewitt N, Ruble JC, Padgett LR, Woerly EM, Peterson JA, Coskun T, Liu Z, Coutant DE, Ai M, Emmerson PJ, Sangwung P, Willard FS. Sloop KW, et al. Among authors: coutant de. Sci Transl Med. 2024 Dec 18;16(778):eadp5765. doi: 10.1126/scitranslmed.adp5765. Epub 2024 Dec 18. Sci Transl Med. 2024. PMID: 39693407
24 results