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Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases.
Hu XV, Chen X, Han KC, Mildvan AS, Liu JO. Hu XV, et al. Biochemistry. 2007 Nov 6;46(44):12833-43. doi: 10.1021/bi701127x. Epub 2007 Oct 11. Biochemistry. 2007. PMID: 17929833
Hence, at least two Co2+ ions, which may act cooperatively, are needed to promote catalysis, providing kinetic evidence for the functioning of both Co2+ ions of the binuclear complex found in the X-ray structure of E. coli MetAP [Roderick, S. L. and Matthews, B. W. (1993) …
Hence, at least two Co2+ ions, which may act cooperatively, are needed to promote catalysis, providing kinetic evidence for the functioning …
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