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WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, Hebert SC, Gimenez I, Gamba G, Lifton RP. Rinehart J, et al. Among authors: de los heros p. Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16777-82. doi: 10.1073/pnas.0508303102. Epub 2005 Nov 7. Proc Natl Acad Sci U S A. 2005. PMID: 16275913 Free PMC article.
A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity.
Moreno E, Tovar-Palacio C, de los Heros P, Guzmán B, Bobadilla NA, Vázquez N, Riccardi D, Poch E, Gamba G. Moreno E, et al. Among authors: de los heros p. J Biol Chem. 2004 Apr 16;279(16):16553-60. doi: 10.1074/jbc.M400602200. Epub 2004 Feb 5. J Biol Chem. 2004. PMID: 14766743 Free article.
WNK kinases, renal ion transport and hypertension.
San-Cristobal P, de los Heros P, Ponce-Coria J, Moreno E, Gamba G. San-Cristobal P, et al. Among authors: de los heros p. Am J Nephrol. 2008;28(5):860-70. doi: 10.1159/000139639. Epub 2008 Jun 12. Am J Nephrol. 2008. PMID: 18547946 Free PMC article. Review.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Ponce-Coria J, et al. Among authors: de los heros p. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8458-63. doi: 10.1073/pnas.0802966105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550832 Free PMC article.
25 results