Dexheimer TS - Search Results

1

Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity.

Fellows IM, Schwaebe M, Dexheimer TS, Vankayalapati H, Gleason-Guzman M, Whitten JP, Hurley LH. Fellows IM, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2005 Nov;4(11):1729-39. doi: 10.1158/1535-7163.MCT-05-0183. Mol Cancer Ther. 2005. PMID: 16275994

2

Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.

Heald RA, Dexheimer TS, Vankayalapati H, Siddiqui-Jain A, Szabo LZ, Gleason-Guzman MC, Hurley LH. Heald RA, et al. Among authors: dexheimer ts. J Med Chem. 2005 Apr 21;48(8):2993-3004. doi: 10.1021/jm049299c. J Med Chem. 2005. PMID: 15828838

3

Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.

Dexheimer TS, Sun D, Hurley LH. Dexheimer TS, et al. J Am Chem Soc. 2006 Apr 26;128(16):5404-15. doi: 10.1021/ja0563861. J Am Chem Soc. 2006. PMID: 16620112 Free PMC article.

4

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III(1).

Dexheimer TS, Carey SS, Zuohe S, Gokhale VM, Hu X, Murata LB, Maes EM, Weichsel A, Sun D, Meuillet EJ, Montfort WR, Hurley LH. Dexheimer TS, et al. Mol Cancer Ther. 2009 May;8(5):1363-77. doi: 10.1158/1535-7163.MCT-08-1093. Epub 2009 May 12. Mol Cancer Ther. 2009. PMID: 19435876 Free PMC article.

5

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.

Takagi K, Dexheimer TS, Redon C, Sordet O, Agama K, Lavielle G, Pierré A, Bates SE, Pommier Y. Takagi K, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3229-38. doi: 10.1158/1535-7163.MCT-07-0441. Mol Cancer Ther. 2007. PMID: 18089716

6

Molecular and cellular pharmacology of the novel noncamptothecin topoisomerase I inhibitor Genz-644282.

Sooryakumar D, Dexheimer TS, Teicher BA, Pommier Y. Sooryakumar D, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2011 Aug;10(8):1490-9. doi: 10.1158/1535-7163.MCT-10-1043. Epub 2011 Jun 2. Mol Cancer Ther. 2011. PMID: 21636699 Free PMC article.

7

Biochemical assays for the discovery of TDP1 inhibitors.

Marchand C, Huang SY, Dexheimer TS, Lea WA, Mott BT, Chergui A, Naumova A, Stephen AG, Rosenthal AS, Rai G, Murai J, Gao R, Maloney DJ, Jadhav A, Jorgensen WL, Simeonov A, Pommier Y. Marchand C, et al. Among authors: dexheimer ts. Mol Cancer Ther. 2014 Aug;13(8):2116-26. doi: 10.1158/1535-7163.MCT-13-0952. Epub 2014 Jul 14. Mol Cancer Ther. 2014. PMID: 25024006 Free PMC article.

8

Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor.

Gheeya J, Johansson P, Chen QR, Dexheimer T, Metaferia B, Song YK, Wei JS, He J, Pommier Y, Khan J. Gheeya J, et al. Cancer Lett. 2010 Jul 1;293(1):124-31. doi: 10.1016/j.canlet.2010.01.004. Epub 2010 Feb 4. Cancer Lett. 2010. PMID: 20133050 Free PMC article.

9

Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M. Peterson KE, et al. Among authors: dexheimer ts. J Med Chem. 2011 Jul 28;54(14):4937-53. doi: 10.1021/jm101338z. Epub 2011 Jun 28. J Med Chem. 2011. PMID: 21710981 Free PMC article.

10

Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity.

Goswami A, Qiu S, Dexheimer TS, Ranganathan P, Burikhanov R, Pommier Y, Rangnekar VM. Goswami A, et al. Among authors: dexheimer ts. Cancer Res. 2008 Aug 1;68(15):6190-8. doi: 10.1158/0008-5472.CAN-08-0831. Cancer Res. 2008. PMID: 18676842 Free PMC article.

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