Margison GP - Search Results

1

O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts.

Clemons M, Kelly J, Watson AJ, Howell A, McElhinney RS, McMurry TB, Margison GP. Clemons M, et al. Among authors: margison gp. Br J Cancer. 2005 Nov 14;93(10):1152-6. doi: 10.1038/sj.bjc.6602833. Br J Cancer. 2005. PMID: 16278661 Free PMC article.

2

Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase.

Barvaux VA, Lorigan P, Ranson M, Gillum AM, McElhinney RS, McMurry TB, Margison GP. Barvaux VA, et al. Among authors: margison gp. Mol Cancer Ther. 2004 Oct;3(10):1215-20. Mol Cancer Ther. 2004. PMID: 15486188

3

Lomeguatrib, a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors.

Ranson M, Middleton MR, Bridgewater J, Lee SM, Dawson M, Jowle D, Halbert G, Waller S, McGrath H, Gumbrell L, McElhinney RS, Donnelly D, McMurry TB, Margison GP. Ranson M, et al. Among authors: margison gp. Clin Cancer Res. 2006 Mar 1;12(5):1577-84. doi: 10.1158/1078-0432.CCR-05-2198. Clin Cancer Res. 2006. PMID: 16533784 Clinical Trial.

4

Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model.

Middleton MR, Thatcher N, McMurry TB, McElhinney RS, Donnelly DJ, Margison GP. Middleton MR, et al. Among authors: margison gp. Int J Cancer. 2002 Aug 10;100(5):615-7. doi: 10.1002/ijc.10532. Int J Cancer. 2002. PMID: 12124813

5

Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer.

Clemons M, Ranson M, Margison JM, El Teraifi H, Griffiths A, Kelly J, Morris CQ, Howell A, Margison GP. Clemons M, et al. Among authors: margison jm, margison gp. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849. Int J Cancer. 2003. PMID: 12494480

6

Dual repair modulation reverses Temozolomide resistance in vitro.

Barvaux VA, Ranson M, Brown R, McElhinney RS, McMurry TB, Margison GP. Barvaux VA, et al. Among authors: margison gp. Mol Cancer Ther. 2004 Feb;3(2):123-7. Mol Cancer Ther. 2004. PMID: 14985452

7

O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.

Fairbairn LJ, Watson AJ, Rafferty JA, Elder RH, Margison GP. Fairbairn LJ, et al. Among authors: margison gp. Exp Hematol. 1995 Feb;23(2):112-6. Exp Hematol. 1995. PMID: 7828668

8

Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells.

Baer JC, Freeman AA, Newlands ES, Watson AJ, Rafferty JA, Margison GP. Baer JC, et al. Among authors: margison gp. Br J Cancer. 1993 Jun;67(6):1299-302. doi: 10.1038/bjc.1993.241. Br J Cancer. 1993. PMID: 8512814 Free PMC article.

9

Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice.

Bibby MC, Thompson MJ, Rafferty JA, Margison GP, McElhinney RS. Bibby MC, et al. Among authors: margison gp. Br J Cancer. 1999 Mar;79(9-10):1332-9. doi: 10.1038/sj.bjc.6690215. Br J Cancer. 1999. PMID: 10188873 Free PMC article.

10

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

Middleton MR, Kelly J, Thatcher N, Donnelly DJ, McElhinney RS, McMurry TB, McCormick JE, Margison GP. Middleton MR, et al. Among authors: margison gp. Int J Cancer. 2000 Jan 15;85(2):248-52. doi: 10.1002/(sici)1097-0215(20000115)85:2<248::aid-ijc16>3.0.co;2-v. Int J Cancer. 2000. PMID: 10629085

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