Clarke AR - Search Results

1

Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.

Hay T, Jenkins H, Sansom OJ, Martin NM, Smith GC, Clarke AR. Hay T, et al. Among authors: clarke ar. Cancer Res. 2005 Nov 15;65(22):10145-8. doi: 10.1158/0008-5472.CAN-05-1186. Cancer Res. 2005. PMID: 16287996

2

Analyzing tumor suppressor activities in the murine small intestine.

Clarke AR, Sansom OJ. Clarke AR, et al. Oncol Res. 2003;13(6-10):333-7. doi: 10.3727/096504003108748537. Oncol Res. 2003. PMID: 12725522 Review.

3

Mutations in Apc and p53 synergize to promote mammary neoplasia.

Méniel V, Hay T, Douglas-Jones A, Sansom OJ, Clarke AR. Méniel V, et al. Among authors: clarke ar. Cancer Res. 2005 Jan 15;65(2):410-6. Cancer Res. 2005. PMID: 15695381

4

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.

Hay T, Patrick T, Winton D, Sansom OJ, Clarke AR. Hay T, et al. Among authors: clarke ar. Oncogene. 2005 May 26;24(23):3842-6. doi: 10.1038/sj.onc.1208533. Oncogene. 2005. PMID: 15735671

5

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR. Hay T, et al. Among authors: clarke ar. Cancer Res. 2009 May 1;69(9):3850-5. doi: 10.1158/0008-5472.CAN-08-2388. Epub 2009 Apr 21. Cancer Res. 2009. PMID: 19383921

6

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cole AM, et al. Among authors: clarke ar. Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Cancer Res. 2010. PMID: 20736363 Free PMC article.

7

DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data.

Hay T, Clarke AR. Hay T, et al. Among authors: clarke ar. Biochem Soc Trans. 2005 Aug;33(Pt 4):715-7. doi: 10.1042/BST0330715. Biochem Soc Trans. 2005. PMID: 16042582 Review.

8

Deficiency of Mbd2 suppresses intestinal tumorigenesis.

Sansom OJ, Berger J, Bishop SM, Hendrich B, Bird A, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. Nat Genet. 2003 Jun;34(2):145-7. doi: 10.1038/ng1155. Nat Genet. 2003. PMID: 12730693

9

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. J Biol Chem. 2005 Aug 5;280(31):28463-7. doi: 10.1074/jbc.M500191200. Epub 2005 Jun 9. J Biol Chem. 2005. PMID: 15946945 Free article.

10

Apc deficiency predisposes to renal carcinoma in the mouse.

Sansom OJ, Griffiths DF, Reed KR, Winton DJ, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. Oncogene. 2005 Dec 8;24(55):8205-10. doi: 10.1038/sj.onc.1208956. Oncogene. 2005. PMID: 16116480

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