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A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.
Twine S, Byström M, Chen W, Forsman M, Golovliov I, Johansson A, Kelly J, Lindgren H, Svensson K, Zingmark C, Conlan W, Sjöstedt A. Twine S, et al. Among authors: forsman m. Infect Immun. 2005 Dec;73(12):8345-52. doi: 10.1128/IAI.73.12.8345-8352.2005. Infect Immun. 2005. PMID: 16299332 Free PMC article.
Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis.
Broekhuijsen M, Larsson P, Johansson A, Byström M, Eriksson U, Larsson E, Prior RG, Sjöstedt A, Titball RW, Forsman M. Broekhuijsen M, et al. Among authors: forsman m. J Clin Microbiol. 2003 Jul;41(7):2924-31. doi: 10.1128/JCM.41.7.2924-2931.2003. J Clin Microbiol. 2003. PMID: 12843022 Free PMC article.
254 results