Smith AJ - Search Results

1

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, Seabrook GR, Atack JR. Dawson GR, et al. Among authors: smith aj. J Pharmacol Exp Ther. 2006 Mar;316(3):1335-45. doi: 10.1124/jpet.105.092320. Epub 2005 Dec 2. J Pharmacol Exp Ther. 2006. PMID: 16326923

2

Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors.

Pillai GV, Smith AJ, Hunt PA, Simpson PB. Pillai GV, et al. Among authors: smith aj. Biochem Pharmacol. 2004 Sep 1;68(5):819-31. doi: 10.1016/j.bcp.2004.05.013. Biochem Pharmacol. 2004. PMID: 15294445

3

In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.

Atack JR, Alder L, Cook SM, Smith AJ, McKernan RM. Atack JR, et al. Among authors: smith aj. Neuropharmacology. 2005 Aug;49(2):220-9. doi: 10.1016/j.neuropharm.2005.03.004. Epub 2005 Apr 26. Neuropharmacology. 2005. PMID: 15996568

4

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, Smith A, Otu FM, Howell O, Atack JR, McKernan RM, Seabrook GR, Dawson GR, Whiting PJ, Rosahl TW. Collinson N, et al. J Neurosci. 2002 Jul 1;22(13):5572-80. doi: 10.1523/JNEUROSCI.22-13-05572.2002. J Neurosci. 2002. PMID: 12097508 Free PMC article.

5

Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor.

Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM. Dawson GR, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1051-60. J Pharmacol Exp Ther. 2000. PMID: 11082440

6

Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux.

Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR. Smith AJ, et al. Mol Pharmacol. 2001 May;59(5):1108-18. doi: 10.1124/mol.59.5.1108. Mol Pharmacol. 2001. PMID: 11306694

7

Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors.

Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA. Thompson SA, et al. Among authors: smith aj. Br J Pharmacol. 2004 May;142(1):97-106. doi: 10.1038/sj.bjp.0705689. Epub 2004 Apr 20. Br J Pharmacol. 2004. PMID: 15100159 Free PMC article.

8

Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.

Smith AJ, Oxley B, Malpas S, Pillai GV, Simpson PB. Smith AJ, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):601-9. doi: 10.1124/jpet.104.070342. Epub 2004 Jun 21. J Pharmacol Exp Ther. 2004. PMID: 15210837

9

Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, Wafford KA, Sheppard WF, Tye SJ. Jennings AS, et al. Among authors: smith aj. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1477-80. doi: 10.1016/j.bmcl.2005.12.044. Epub 2006 Jan 4. Bioorg Med Chem Lett. 2006. PMID: 16386900

10

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, Wafford KA, Marshall G, Castro JL, Atack JR. Goodacre SC, et al. Among authors: smith aj. J Med Chem. 2006 Jan 12;49(1):35-8. doi: 10.1021/jm051065l. J Med Chem. 2006. PMID: 16392789

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