Lou K - Search Results

1

Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.

Wang Y, Perchellet EM, Ward MM, Lou K, Zhao H, Battina SK, Wiredu B, Hua DH, Perchellet JP. Wang Y, et al. Among authors: lou k. Int J Oncol. 2006 Jan;28(1):161-72. Int J Oncol. 2006. PMID: 16327993

2

Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.

Perchellet EM, Wang Y, Weber RL, Sperfslage BJ, Lou K, Crossland J, Hua DH, Perchellet JP. Perchellet EM, et al. Among authors: lou k. Biochem Pharmacol. 2004 Feb 1;67(3):523-37. doi: 10.1016/j.bcp.2003.09.012. Biochem Pharmacol. 2004. PMID: 15037204

3

Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.

Perchellet EM, Wang Y, Weber RL, Lou K, Hua DH, Perchellet JP. Perchellet EM, et al. Among authors: lou k. Anticancer Drugs. 2004 Nov;15(10):929-46. doi: 10.1097/00001813-200411000-00002. Anticancer Drugs. 2004. PMID: 15514562

4

Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

Wang Y, Perchellet EM, Ward MM, Lou K, Hua DH, Perchellet JP. Wang Y, et al. Among authors: lou k. Anticancer Drugs. 2005 Oct;16(9):953-67. doi: 10.1097/01.cad.0000180123.24031.5a. Anticancer Drugs. 2005. PMID: 16162972

5

Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs.

Hua DH, Lou K, Battina SK, Zhao H, Perchellet EM, Wang Y, Perchellet JP. Hua DH, et al. Among authors: lou k. Anticancer Agents Med Chem. 2006 Jul;6(4):303-18. doi: 10.2174/187152006777698141. Anticancer Agents Med Chem. 2006. PMID: 16842233 Review.

6

Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.

Yamada T, Komoto J, Lou K, Ueki A, Hua DH, Sugiyama K, Takata Y, Ogawa H, Takusagawa F. Yamada T, et al. Among authors: lou k. Biochem Pharmacol. 2007 Apr 1;73(7):981-9. doi: 10.1016/j.bcp.2006.12.014. Epub 2006 Dec 14. Biochem Pharmacol. 2007. PMID: 17214973

7

Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.

Perchellet EM, Wang Y, Lou K, Zhao H, Battina SK, Hua DH, Perchellet JP. Perchellet EM, et al. Among authors: lou k. Int J Oncol. 2007 Nov;31(5):1231-41. Int J Oncol. 2007. PMID: 17912452

8

Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.

Perchellet EM, Wang Y, Lou K, Zhao H, Battina SK, Hua DH, Perchellet JP. Perchellet EM, et al. Among authors: lou k. Anticancer Res. 2007 Sep-Oct;27(5A):3259-71. Anticancer Res. 2007. PMID: 17970069 Free article.

9

Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities.

Hua DH, Zhao H, Battina SK, Lou K, Jimenez AL, Desper J, Perchellet EM, Perchellet JP, Chiang PK. Hua DH, et al. Among authors: lou k. Bioorg Med Chem. 2008 May 1;16(9):5232-46. doi: 10.1016/j.bmc.2008.03.009. Epub 2008 Mar 6. Bioorg Med Chem. 2008. PMID: 18356059 Free PMC article.

10

Synthesis of cyclododeciptycene quinones.

Lou K, Prior AM, Wiredu B, Desper J, Hua DH. Lou K, et al. J Am Chem Soc. 2010 Dec 15;132(49):17635-41. doi: 10.1021/ja1088309. Epub 2010 Nov 22. J Am Chem Soc. 2010. PMID: 21090722

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